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Sinonasal cancer and exposure to styrene
  1. E Clare Harris1,2,
  2. Karen Walker-Bone1,2,
  3. Georgia Ntani1,2,
  4. David Coggon1,2
  1. 1MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK
  2. 2Arthritis Research UK/MRC Centre for Musculoskeletal Health and Work, University of Southampton, Southampton, UK
  1. Correspondence to Dr E Clare Harris, MRC Lifecourse Epidemiology Unit (University of Southampton), Southampton General Hospital, Southampton SO16 6YD, UK; ech{at}

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We read with interest the recent article by Nissen et al,1 which described a possible association of sinonasal adenocarcinoma with occupational exposure to styrene in the production of glass-reinforced plastics. Noting the limited statistical significance of their finding, and the potential for uncontrolled residual confounding by occupational exposure to wood dust, the authors called for further studies to confirm or refute the hazard.

During the 1980s we …

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  • Contributors All authors wrote and agreed with the letter following revisit of their previous analysis.

  • Funding This study was funded by Colt Foundation (grant no: CF/03/10).

  • Competing interests None declared.

  • Patient consent Not required.

  • Ethics approval National Research Ethics Service Committee South Central - Portsmouth.

  • Provenance and peer review Not commissioned; internally peer reviewed.