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Toxicology of Metals
31 The association of blood lead level and serum lipid concentrations may be modified by metallothionein 2a polymorphisms
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  1. Chen-Cheng Yang1,2,3,4,5,
  2. Chih-Shien Chuang5,
  3. Chia-I Lin1,2,3,4,
  4. Chao-Ling Wang3,
  5. Yung-Cheng Huang6,
  6. Hung-Yi Chuang3,5,7
  1. 1Health Management Centre, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
  2. 2Health Management Centre, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan
  3. 3Department of Environmental and Occupational Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
  4. 4Department of Environmental and Occupational Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan
  5. 5Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
  6. 6Department of Family Medicine, Pingtung Christian Hospital, Pingtung, Taiwan
  7. 7Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan

Abstract

Introduction Lead in blood can stimulate lipid oxidation in phosphatidylcholine and increase peroxidation in lipids. Metallothionein (MT) is a cysteine rich protein that can influence the detoxification of heavy metals and scavenge oxidative stress for free radicals. One of the most expressive functional genes in humans is the MT2A gene.

This study aims to determine if the association of the blood lead level and lipid biomarkers was influenced by MT2A polymorphisms.

Methods We recruited 677 participants after informed consent was obtained. All of the samples collected were analysed for lipid biomarkers and blood lead levels and were genotyped for MT2A polymorphisms by RT-PCR. A short questionnaire collected the medical history and alcohol and cigarette consumption information. The data were used for descriptive analyses and linear regression models.

Result The investigation revealed that lead elevated concentration increased low-density lipoprotein cholesterol (LDL-C) and decreased high-density lipoprotein cholesterol (HDL-C) by multiple linear models. The carriers of the rs10636 GC-rs28366003 AA genetic combination may be less susceptive to lead elevated concentration on HDL-C than other types.

Conclusion In conclusion, the association of the blood lead level and HDL-C may be modified by the MT2A genetic combination: the rs10636 GC-rs28366003 AA genotype could play a protective role in lead elevated concentration on HDL-C in humans.

  • Lead
  • Metallothionein
  • High-Density Lipoprotein Cholesterol

https://doi.org/10.1136/oemed-2018-ICOHabstracts.1448

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