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Oral presentations: Day 2: Thursday, September 8, 2011
Lymphatic neoplasms
Lymphoma risk among animal breeders
Free
  1. Ileana D'Andrea1,
  2. Maria Grazia Ennas1,
  3. Giannina Satta1,
  4. Mariagrazia Zucca1,
  5. Tinucia Nonne1,
  6. Andrea ‘t Mannetje2,
  7. Nikolaus Becker3,
  8. Silvia De Sanjosé4,
  9. Lenka Foretova5,
  10. Anthony Staines6,
  11. Marc Maynadié7,
  12. Alexandra Nieters3,
  13. Paul Brennan8,
  14. Paolo Boffetta9,
  15. Michele Meloni1,
  16. Pierluigi Cocco1
  1. 1University of Cagliari, Cagliari, Italy
  2. 2Massey University, Wellington, New Zealand
  3. 3German Cancer Research Center, Heidelberg, Germany
  4. 4Catalan Institute of Oncology, Barcelona, Spain
  5. 5Department of Cancer Epidemiology and Genetics, Brno, Czech Republic
  6. 6Dublin City University, Dublin, Ireland
  7. 7Dijon University Hospital, Dijon, France
  8. 8IARC, Lyon, France
  9. 9Mount Sinai School of Medicine, New York, USA

Abstract

Objectives Occupational contact with breeding animals might be implicated in lymphoma aetiology.

Methods In 1998–2003, 2337 incident lymphoma cases and 2434 controls participated in the EPILYMPH case-control study in six European countries. A detailed occupational history was collected in cases and controls, including species of breeding animals, their approximate number, and circumstances of contact. We conducted a preliminary analysis on ever exposed to contact with breeding animals, and we stratified the analysis by age at first exposure, whether before or after 12. The OR and its 95% CI was calculated with unconditional logistic regression for all lymphomas, and its major subtypes, adjusting by age, gender, and education.

Results Lymphoma risk (all subtypes combined) did not increase among those exposed to contact with breeding animals (OR = 1.0, 95% CI 0.8 to 1.2). Risk of DLBCL was significantly lower among subjects employed in poultry farms (OR = 0.6, 95% CI 0.4 to 1.0). This inverse association was observed among subjects who started exposure before or at age 12 (OR = 0.5, 95% CI 0.2 to 1.1), but not later.

Conclusions Early occupational contact with poultry might be associated with a decrease in risk of specific lymphoma subtypes.

https://doi.org/10.1136/oemed-2011-100382.111

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