The old herbal drug aristolochic acid (AA), derived from Aristolochia spp., has been
associated with the development of a novel nephropathy, designated aristolochic acid …

Balkan endemic nephropathy (BEN) is found in certain rural areas of the Balkans and affects
at least 25 000 inhabitants. Of the many hypotheses on BEN, the Aristolochia hypothesis has …

It has been 20 years since the first description of a rapidly progressive renal disease that is
associated with the consumption of Chinese herbs containing aristolochic acid (AA) and is …

Background Chinese-herb nephropathy is a progressive form of renal fibrosis that develops
in some patients who take weight-reducing pills containing Chinese herbs. Because of a …

Summary Whole-genome-sequencing (WGS) of human tumors has revealed distinct
mutation patterns that hint at the causative origins of cancer. We examined mutational …

Background This study explores and characterizes cell cycle alterations induced by urban
PM2. 5 in the human epithelial cell line BEAS-2B, and elucidates possible mechanisms …

Whole genome sequencing of human tumours has revealed distinct patterns of mutation that
hint at the causative origins of cancer. Experimental investigations of the mutations and …

Abstract 32P-postlabeling analysis is an ultrasensitive method for the detection and
quantitation of carcinogen–DNA adducts. It consists of four principal steps:(i) enzymatic …

The polycyclic aromatic hydrocarbon (PAH), benzo [a] pyrene (BaP), was compared to
dibenzo [def, p] chrysene (DBC) and combinations of three environmental PAH mixtures …

A genotoxin is a chemical or agent that can cause DNA or chromosomal damage. Such
damage in a germ cell has the potential to cause a heritable altered trait (germline mutation) …