Nutritional programming of the metabolic syndrome
ME Symonds, SP Sebert, MA Hyatt… - Nature Reviews …, 2009 - nature.com
The primary markers of the metabolic syndrome are central obesity, insulin resistance and
hypertension. In this review, we consider the effect of changes in maternal nutrition during …
hypertension. In this review, we consider the effect of changes in maternal nutrition during …
Genome-wide associations for birth weight and correlations with adult disease
Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in
observational studies is reproducibly associated with future risk of adult metabolic diseases …
observational studies is reproducibly associated with future risk of adult metabolic diseases …
[HTML][HTML] Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study
KS Vimaleswaran, A Cavadino, DJ Berry… - The lancet Diabetes & …, 2014 - thelancet.com
Background Low plasma 25-hydroxyvitamin D (25 [OH] D) concentration is associated with
high arterial blood pressure and hypertension risk, but whether this association is causal is …
high arterial blood pressure and hypertension risk, but whether this association is causal is …
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
Birth weight within the normal range is associated with a variety of adult-onset diseases, but
the mechanisms behind these associations are poorly understood. Previous genome-wide …
the mechanisms behind these associations are poorly understood. Previous genome-wide …
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index
JF Felix, JP Bradfield, C Monnereau… - Human molecular …, 2016 - academic.oup.com
A large number of genetic loci are associated with adult body mass index. However, the
genetics of childhood body mass index are largely unknown. We performed a meta-analysis …
genetics of childhood body mass index are largely unknown. We performed a meta-analysis …
[HTML][HTML] Genetic evidence for causal relationships between maternal obesity-related traits and birth weight
Importance Neonates born to overweight or obese women are larger and at higher risk of
birth complications. Many maternal obesity-related traits are observationally associated with …
birth complications. Many maternal obesity-related traits are observationally associated with …
The association between diabetes and cognitive changes during aging
S Papunen, A Mustakallio-Könönen… - … Journal of Primary …, 2020 - Taylor & Francis
Background Worldwide, we are observing a rising prevalence of dementia and mild
cognitive impairments that often co-occur with the heightened incidence of non …
cognitive impairments that often co-occur with the heightened incidence of non …
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function
We determined the relationships between DNA sequence variation and DNA methylation
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify …
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify …
[HTML][HTML] Epigenome-wide meta-analysis of DNA methylation and childhood asthma
Background Epigenetic mechanisms, including methylation, can contribute to childhood
asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease …
asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease …
Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal …
RN Beaumont, NM Warrington… - Human molecular …, 2018 - academic.oup.com
Genome-wide association studies of birth weight have focused on fetal genetics, whereas
relatively little is known about the role of maternal genetic variation. We aimed to identify …
relatively little is known about the role of maternal genetic variation. We aimed to identify …