Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes

JM Anto, J Bousquet, M Akdis, C Auffray, T Keil… - Journal of Allergy and …, 2017 - Elsevier
Asthma, rhinitis, and eczema are complex diseases with multiple genetic and environmental
factors interlinked through IgE-associated and non–IgE-associated mechanisms …

[HTML][HTML] Lung-function trajectories leading to chronic obstructive pulmonary disease

P Lange, B Celli, A Agustí, G Boje Jensen… - … England Journal of …, 2015 - Mass Medical Soc
Background Chronic obstructive pulmonary disease (COPD) is thought to result from an
accelerated decline in forced expiratory volume in 1 second (FEV1) over time. Yet it is …

Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis

J Bousquet, E Melén, T Haahtela, GH Koppelman… - Allergy, 2023 - Wiley Online Library
Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly
overlap in the human interactome. The concept of “one‐airway‐one‐disease,” coined over …

Rhinitis as an independent risk factor for adult-onset asthma

S Guerra, DL Sherrill, FD Martinez… - Journal of Allergy and …, 2002 - Elsevier
Background: For many years, the association between asthma and rhinitis has primarily
been attributed to a common allergic background. Recently, it has been suggested that …

[PDF][PDF] DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis

BR Joubert, JF Felix, P Yousefi, KM Bakulski… - The American Journal of …, 2016 - cell.com
Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …

Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence

WJ Morgan, DA Stern, DL Sherrill, S Guerra… - American journal of …, 2005 - atsjournals.org
Rationale: The effect of early life wheezing on respiratory function and continued symptoms
through adolescence has not been fully described. Using data from a population-based birth …

Poor airway function in early infancy and lung function by age 22 years: a non-selective longitudinal cohort study

DA Stern, WJ Morgan, AL Wright, S Guerra… - The Lancet, 2007 - thelancet.com
Background Together with smoking, the lung function attained in early adulthood is one of
the strongest predictors of chronic obstructive pulmonary disease. We aimed to investigate …

Asthma as a risk factor for COPD in a longitudinal study

GE Silva, DL Sherrill, S Guerra, RA Barbee - Chest, 2004 - Elsevier
Background: For several years, asthma and COPD have been regarded as distinct entities,
with distinct clinical courses. However, despite distinctive physiologic features at the time of …

Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: a Mechanisms of the Development of Allergy (MeDALL) seminar

JM Antó, M Pinart, M Akdis, C Auffray, C Bachert… - Journal of Allergy and …, 2012 - Elsevier
Mechanisms of the Development of Allergy (MeDALL), a Seventh Framework Program
European Union project, aims to generate novel knowledge on the mechanisms of initiation …

The relation of body mass index to asthma, chronic bronchitis, and emphysema

S Guerra, DL Sherrill, A Bobadilla, FD Martinez… - Chest, 2002 - Elsevier
Background Recent studies have suggested a relationship between asthma and obesity.
Despite these reports, the effect of being underweight or overweight as a risk factor for …