Identification of genetic susceptibility loci for colorectal tumors in a genome-wide meta-analysis
BACKGROUND & AIMS: Heritable factors contribute to the development of colorectal
cancer. Identifying the genetic loci associated with colorectal tumor formation could …
cancer. Identifying the genetic loci associated with colorectal tumor formation could …
Genetic studies of body mass index yield new insights for obesity biology
AE Locke, B Kahali, SI Berndt, AE Justice, TH Pers… - Nature, 2015 - nature.com
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of
obesity better, here we conduct a genome-wide association study and Metabochip meta …
obesity better, here we conduct a genome-wide association study and Metabochip meta …
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
EK Speliotes, CJ Willer, SI Berndt, KL Monda… - Nature …, 2010 - nature.com
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …
Hundreds of variants clustered in genomic loci and biological pathways affect human height
H Lango Allen, K Estrada, G Lettre, SI Berndt… - Nature, 2010 - nature.com
Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association …
sequence variants at many genetic loci influence the phenotype. Genome-wide association …
Common variants near MC4R are associated with fat mass, weight and risk of obesity
To identify common variants influencing body mass index (BMI), we analyzed genome-wide
association data from 16,876 individuals of European descent. After previously reported …
association data from 16,876 individuals of European descent. After previously reported …
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Approaches exploiting trait distribution extremes may be used to identify loci associated with
common traits, but it is unknown whether these loci are generalizable to the broader …
common traits, but it is unknown whether these loci are generalizable to the broader …
Multiple loci identified in a genome-wide association study of prostate cancer
We followed our initial genome-wide association study (GWAS) of 527,869 SNPs on 1,172
individuals with prostate cancer and 1,157 controls of European origin—nested in the …
individuals with prostate cancer and 1,157 controls of European origin—nested in the …
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
FR Schumacher, AA Al Olama, SI Berndt, S Benlloch… - Nature …, 2018 - nature.com
Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified
more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data …
more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data …
Identification of ten loci associated with height highlights new biological pathways in human growth
G Lettre, AU Jackson, C Gieger, FR Schumacher… - Nature …, 2008 - nature.com
Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet-
undiscovered genetic factors. We carried out a meta-analysis of genome-wide association …
undiscovered genetic factors. We carried out a meta-analysis of genome-wide association …