Technological and economic potential of poly (lactic acid) and lactic acid derivatives

R Datta, SP Tsai, P Bonsignore… - FEMS microbiology …, 1995 - academic.oup.com
Lactic acid has been an intermediate-volume specialty chemical (world production∼ 40,000
tons/yr) used in a wide range of food processing and industrial applications. Lactic acid has …

Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort study

CP Wen, JPM Wai, MK Tsai, YC Yang, TYD Cheng… - The lancet, 2011 - thelancet.com
Background The health benefits of leisure-time physical activity are well known, but whether
less exercise than the recommended 150 min a week can have life expectancy benefits is …

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

JR Junutula, H Raab, S Clark, S Bhakta… - Nature …, 2008 - nature.com
Antibody-drug conjugates enhance the antitumor effects of antibodies and reduce adverse
systemic effects of potent cytotoxic drugs. However, conventional drug conjugation …

All-cause mortality attributable to chronic kidney disease: a prospective cohort study based on 462 293 adults in Taiwan

CP Wen, TYD Cheng, MK Tsai, YC Chang, HT Chan… - The lancet, 2008 - thelancet.com
Background Both end-stage renal disease and chronic kidney disease are increasing
worldwide; however, the full effect of chronic kidney disease is unknown because mortality …

Asbestos related diseases from environmental exposure to crocidolite in Da-yao, China. I. Review of exposure and epidemiological data

S Luo, X Liu, S Mu, SP Tsai, CP Wen - … and environmental medicine, 2003 - oem.bmj.com
Background: Scattered patches of crocidolite, one form of asbestos, were found in the
surface soil in the rural county of Da-yao in southwestern China. In 1983, researchers from …

Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes

L Fu, LM John, SH Adams, XX Yu, E Tomlinson… - …, 2004 - academic.oup.com
Hormonal control of metabolic rate can be important in regulating the imbalance between
energy intake and expenditure that underlies the development of obesity. In mice fed a high …

Are Asians at greater mortality risks for being overweight than Caucasians? Redefining obesity for Asians

CP Wen, TYD Cheng, SP Tsai, HT Chan… - Public health …, 2009 - cambridge.org
ObjectivesTo assess whether overweight Asians, assessed on the basis of WHO criteria, are
at greater mortality risk than overweight Caucasians, and to determine whether alternative …

Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity

E Tomlinson, L Fu, L John, B Hultgren, X Huang… - …, 2002 - academic.oup.com
The fibroblast growth factors (FGFs), and the corresponding receptors, are implicated in
more than just the regulation of epithelial cell proliferation and differentiation. Specifically …

Anatomy of the healthy worker effect: a critical review

CP Wen, SP Tsai, RL Gibson - Journal of Occupational and …, 1983 - journals.lww.com
The healthy worker effect is the composite result from factors such as (1) selection of the
work force,(2) changes in lifestyle accompanying employment, and (3) methodological …

A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice

K Nicholes, S Guillet, E Tomlinson, K Hillan… - The American journal of …, 2002 - Elsevier
Most mouse models of hepatocellular carcinoma have expressed growth factors and
oncogenes under the control of a liver-specific promoter. In contrast, we describe here the …