Many of the genes that affect aging and longevity in model organisms, such as mice, fruit
flies, and worms, have human homologs. This article reviews several genetic pathways that …

During normal ageing, the gradual loss of telomeric DNA in dividing somatic cells can
contribute to replicative senescence, apoptosis, or neoplastic transformation. In the genetic …

Numerous studies demonstrate links between chronic stress and indices of poor health,
including risk factors for cardiovascular disease and poorer immune function. Nevertheless …

It has long been presumed impossible to measure telomeres in vertebrate DNA by PCR
amplification with oligonucleotide primers designed to hybridize to the TTAGGG and …

The current quantitative polymerase chain reaction (QPCR) assay of telomere length
measures telomere (T) signals in experimental DNA samples in one set of reaction wells …

Overlapping cDNA clones from the translocation breakpoint region (TBR) gene, recently
discovered at the neurofibromatosis type 1 locus and found to be interrupted by deletions …

Three new neurofibromatosis type 1 (NFl) mutations have been detected and characterized.
Pulsed-field gel and Southern blot analyses reveal the mutations lo be deletions of 190, 40 …

The neurofibromatosis type 1 (NFl) protein contains a region of significant sequence
similarity to ras p21 GTPase-activating protein (GAP) and the yeast IRA1 gene product. A …

Summary cDNA walking and sequencing have extended the open reading frame for the
neurofibromatosis type 1 gene (NFT). The new sequence now predicts 2485 amino acids of …

We previously reported that psychological stress is linked to and possibly accelerates
cellular aging, as reflected by lower PBMC telomerase and shortened telomeres …