Current concepts in mild cognitive impairment

RC Petersen, R Doody, A Kurz, RC Mohs… - Archives of …, 2001 - jamanetwork.com
The field of aging and dementia is focusing on the characterization of the earliest stages of
cognitive impairment. Recent research has identified a transitional state between the …

Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke …

PB Gorelick, A Scuteri, SE Black, C DeCarli… - stroke, 2011 - Am Heart Assoc
Background and Purpose—This scientific statement provides an overview of the evidence
on vascular contributions to cognitive impairment and dementia. Vascular contributions to …

A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease

F Jessen, RE Amariglio, M Van Boxtel, M Breteler… - Alzheimer's & …, 2014 - Elsevier
There is increasing evidence that subjective cognitive decline (SCD) in individuals with
unimpaired performance on cognitive tests may represent the first symptomatic …

[PDF][PDF] Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

M DeJesus-Hernandez, IR Mackenzie, BF Boeve… - Neuron, 2011 - cell.com
Several families have been reported with autosomal-dominant frontotemporal dementia
(FTD) and amyotrophic lateral sclerosis (ALS), genetically linked to chromosome 9p21 …

Mild cognitive impairment: clinical characterization and outcome

RC Petersen, GE Smith, SC Waring, RJ Ivnik… - Archives of …, 1999 - jamanetwork.com
Background Subjects with a mild cognitive impairment (MCI) have a memory impairment
beyond that expected for age and education yet are not demented. These subjects are …

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

M Hutton, CL Lendon, P Rizzu, M Baker, S Froelich… - Nature, 1998 - nature.com
Thirteen families have been described with an autosomal dominantly inherited dementia
named frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP …

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

CR Jack, DS Knopman, WJ Jagust, LM Shaw… - The Lancet …, 2010 - thelancet.com
Currently available evidence strongly supports the position that the initiating event in
Alzheimer's disease (AD) is related to abnormal processing of β-amyloid (Aβ) peptide …

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

CR Jack, DS Knopman, WJ Jagust… - The lancet …, 2013 - thelancet.com
In 2010, we put forward a hypothetical model of the major biomarkers of Alzheimer's disease
(AD). The model was received with interest because we described the temporal evolution of …

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

AC Naj, G Jun, GW Beecham, LS Wang… - Nature …, 2011 - nature.com
Abstract The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide
association study of late-onset Alzheimer disease using a three-stage design consisting of a …

Mild cognitive impairment as a diagnostic entity

RC Petersen - Journal of internal medicine, 2004 - Wiley Online Library
The concept of cognitive impairment intervening between normal ageing and very early
dementia has been in the literature for many years. Recently, the construct of mild cognitive …