Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

Schizophrenia is a complex disorder, caused by both genetic and environmental factors and
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …

Reduced fecundity, associated with severe mental disorders, places negative selection
pressure on risk alleles and may explain, in part, why common variants have not been found …

Deletions within the neurexin 1 gene (NRXN1; 2p16. 3) are associated with autism and have
also been reported in two families with schizophrenia. We examined NRXN1, and the …

By analyzing the whole-exome sequences of 4,264 schizophrenia cases, 9,343 controls and
1,077 trios, we identified a genome-wide significant association between rare loss-of …

Background Obesity increases the risk of several chronic diseases, but the extent to which
the obesity-related loss of disease-free years varies by lifestyle category and across …

Deletions and reciprocal duplications of the chromosome 16p13. 1 region have recently
been reported in several cases of autism and mental retardation (MR). As genomic copy …

In developed countries, the majority of all violent crime is committed by a small group of
antisocial recidivistic offenders, but no genes have been shown to contribute to recidivistic …

Many common illnesses, for reasons that have not been identified, differentially affect men
and women. For instance, the autoimmune diseases systemic lupus erythematosus (SLE) …

In Europe there is a renewed focus on relationships between chemical determinands and
ecological impact as a result of the Water Framework Directive (WFD). In this paper we use …