Controlled human exposure experiments with diesel exhaust particles (DEPs) and ozone
serve to illustrate the important role pollutants play in modulating both allergic mechanisms …

Background Chronic obstructive pulmonary disease (COPD) is characterized by chronic
bronchitic and emphysematous components. In one biophysical model, the concentration of …

Rationale: E-cigarettes have become increasingly popular and little is known about their
potential adverse health effects. Objectives: To determine the effects of e-cigarette use on …

Background Present treatment strategies to stratify exacerbation risk in patients with chronic
obstructive pulmonary disease (COPD) rely on a history of two or more events in the …

Background Increased concentrations of eosinophils in blood and sputum in chronic
obstructive pulmonary disease (COPD) have been associated with increased frequency of …

Background We previously described the contributions of increased total airway mucin
concentrations to the pathogenesis and diagnosis of the chronic bronchitic component of …

Rationale: E-cigarettes vaporize propylene glycol/vegetable glycerin (PG/VG), nicotine, and
flavorings. However, the long-term health effects of exposing lungs to vaped e-liquids are …

Rationale: Exposure to ozone causes a decrease in spirometric lung function and an
increase in airway inflammation in healthy young adults at concentrations as low as 0.08 …

Human tracheobronchial epithelial cells grown in air-liquid interface culture have emerged
as a powerful tool for the study of airway biology. In this study, we have investigated whether …

In human airways diseases, including cystic fibrosis (CF) and chronic obstructive pulmonary
disease (COPD), host defense is compromised and airways inflammation and infection often …