Handling of dioxin measurement data in the presence of non-detectable values: overview of available methods and their application in the Seveso chloracne study

A Baccarelli, R Pfeiffer, D Consonni, AC Pesatori… - Chemosphere, 2005 - Elsevier
Exposure measurements of concentrations that are non-detectable or near the detection
limit (DL) are common in environmental research. Proper statistical treatment of non-detects …

Immunologic effects of dioxin: new results from Seveso and comparison with other studies.

A Baccarelli, P Mocarelli, DG Patterson Jr… - Environmental …, 2002 - ehp.niehs.nih.gov
Animal studies indicate that the immune system is one of the most sensitive targets of the
toxic effects of 2, 3, 7, 8-tetrachloro-p-dibenzodioxin (TCDD). TCDD inhibits immunoglobulin …

Genome‐wide association studies of pigmentation and skin cancer: a review and meta‐analysis

MR Gerstenblith, J Shi, MT Landi - Pigment cell & melanoma …, 2010 - Wiley Online Library
Recent genome‐wide association studies (GWAS) identified genetic loci associated with
pigmentation, nevi, and skin cancer. We performed a review and meta‐analysis of GWAS …

Genome partitioning of genetic variation for complex traits using common SNPs

J Yang, TA Manolio, LR Pasquale, E Boerwinkle… - Nature …, 2011 - nature.com
We estimate and partition genetic variation for height, body mass index (BMI), von
Willebrand factor and QT interval (QTi) using 586,898 SNPs genotyped on 11,586 unrelated …

[HTML][HTML] Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival

MT Landi, T Dracheva, M Rotunno, JD Figueroa, H Liu… - PloS one, 2008 - journals.plos.org
Background Tobacco smoking is responsible for over 90% of lung cancer cases, and yet the
precise molecular alterations induced by smoking in lung that develop into cancer and …

Detectable clonal mosaicism and its relationship to aging and cancer

KB Jacobs, M Yeager, W Zhou, S Wacholder, Z Wang… - Nature …, 2012 - nature.com
In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-
wide association studies, we observed large chromosomal abnormalities in a subset of …

Detectable clonal mosaicism from birth to old age and its relationship to cancer

CC Laurie, CA Laurie, K Rice, KF Doheny, LR Zelnick… - Nature …, 2012 - nature.com
We detected clonal mosaicism for large chromosomal anomalies (duplications, deletions
and uniparental disomy) using SNP microarray data from over 50,000 subjects recruited for …

[PDF][PDF] A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma

MT Landi, N Chatterjee, K Yu, LR Goldin… - The american journal of …, 2009 - cell.com
Three genetic loci for lung cancer risk have been identified by genome-wide association
studies (GWAS), but inherited susceptibility to specific histologic types of lung cancer is not …

Cigarette smoking and lung cancer—relative risk estimates for the major histological types from a pooled analysis of case–control studies

B Pesch, B Kendzia, P Gustavsson… - … journal of cancer, 2012 - Wiley Online Library
Lung cancer is mainly caused by smoking, but the quantitative relations between smoking
and histologic subtypes of lung cancer remain inconclusive. By using one of the largest lung …

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

JD McKay, RJ Hung, Y Han, X Zong… - Nature …, 2017 - nature.com
Although several lung cancer susceptibility loci have been identified, much of the heritability
for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European …