Relationship between chemical structure and the occupational asthma hazard of low molecular weight organic compounds
J Jarvis, MJ Seed, R Elton, L Sawyer… - Occupational and …, 2005 - oem.bmj.com
Aims: To investigate quantitatively, relationships between chemical structure and reported
occupational asthma hazard for low molecular weight (LMW) organic compounds; to …
occupational asthma hazard for low molecular weight (LMW) organic compounds; to …
Occupational and work-related respiratory disease attributed to cleaning products
Objectives Exposure to cleaning products has been associated with adverse respiratory
outcomes. This study aimed to investigate the medically reported incidence, trends in …
outcomes. This study aimed to investigate the medically reported incidence, trends in …
Development of mechanism-based structural alerts for respiratory sensitization hazard identification
SJ Enoch, MJ Seed, DW Roberts… - Chemical research in …, 2012 - ACS Publications
This study outlines how mechanistic organic chemistry related to covalent bond formation
can be used to rationalize the ability of low molecular weight chemicals to cause respiratory …
can be used to rationalize the ability of low molecular weight chemicals to cause respiratory …
Progress with Structure–Activity Relationship modelling of occupational chemical respiratory sensitizers
MJ Seed, RM Agius - Current Opinion in Allergy and Clinical …, 2017 - journals.lww.com
Further understanding of the molecular interactions between chemical respiratory
sensitizers and components of human proteins have been obtained from in-vitro and in …
sensitizers and components of human proteins have been obtained from in-vitro and in …
Methods for the prediction of low-molecular-weight occupational respiratory sensitizers
MJ Seed, P Cullinan, RM Agius - Current opinion in allergy and …, 2008 - journals.lww.com
The most pragmatic as well as valid approach for screening large numbers of industrial
chemicals for respiratory sensitization hazard is likely to consist of an algorithm starting with …
chemicals for respiratory sensitization hazard is likely to consist of an algorithm starting with …
Emerging trends in the UK incidence of occupational asthma: should we be worried?
While 15% of adult-onset asthma is estimated to have an occupational cause, there has
been evidence of a downward trend in occupational asthma incidence in several European …
been evidence of a downward trend in occupational asthma incidence in several European …
A refined QSAR model for prediction of chemical asthma hazard
J Jarvis, MJ Seed, SJ Stocks… - Occupational Medicine, 2015 - academic.oup.com
Background A previously developed quantitative structure–activity relationship (QSAR)
model has been extern ally validated as a good predictor of chemical asthma hazard …
model has been extern ally validated as a good predictor of chemical asthma hazard …
Anaphylaxis caused by neostigmine
MJ Seed, PW Ewan - Anaesthesia, 2000 - Wiley Online Library
A patient developed anaphylaxis during anaesthesia, towards the end of surgery, 30 s after
intravenous administration of neostigmine. Anaphylaxis to neostigmine was confirmed by …
intravenous administration of neostigmine. Anaphylaxis to neostigmine was confirmed by …
Chemical determinants of occupational hypersensitivity pneumonitis
MJ Seed, SJ Enoch, RM Agius - Occupational Medicine, 2015 - academic.oup.com
Background Workplace inhalational exposures to low molecular weight (LMW) chemicals
cause hypersensitivity pneumonitis (HP) as well as the more common manifestation of …
cause hypersensitivity pneumonitis (HP) as well as the more common manifestation of …
Insufficient respiratory hazard identification in the safety data sheets for cleaning and disinfection products used in healthcare organisations across England and …
Background Exposure to cleaning and disinfection products has been associated with
respiratory disorders such as asthma in cleaning and healthcare workers. Safety data sheets …
respiratory disorders such as asthma in cleaning and healthcare workers. Safety data sheets …