Multicellular animals detect pathogens via a set of receptors that recognize pathogen-
associated molecular patterns (PAMPs). However, pathogens are not the only causative …

Abstract Background: In late December 2019, Chinese health authorities reported an
outbreak of pneumonia of unknown origin in Wuhan, Hubei Province. Summary: A few days …

Bone mass is a key determinant of fracture risk. Maximizing bone mineral mass during
childhood and adolescence may contribute to fracture risk reduction during adolescence …

Background Somatic mutations in the Janus kinase 2 gene (JAK2) occur in many
myeloproliferative neoplasms, but the molecular pathogenesis of myeloproliferative …

Abstract High mobility group 1 (HMGB1) protein is both a nuclear factor and a secreted
protein. In the cell nucleus it acts as an architectural chromatin-binding factor that bends …

Graphene, a single layer of graphite, has recently attracted considerable attention owing to
its remarkable electronic and structural properties and its possible applications in many …

Epidemiologic studies have demonstrated an inverse association between consumption of
fruits and vegetables and morbidity and mortality from degenerative diseases. The …

Erythropoietin (EPO) is both hematopoietic and tissue protective, putatively through
interaction with different receptors. We generated receptor subtype–selective ligands …

Some of the anti-neoplastic effects of anthracyclines in mice originate from the induction of
innate and T cell–mediated anticancer immune responses. Here we demonstrate that …

HMGB1, a non-histone nuclear factor, acts extracellularly as a mediator of delayed
endotoxin lethality, which raises the question of how a nuclear protein can reach the …