Genetic approaches to understanding post-traumatic stress disorder

LM Almli, N Fani, AK Smith… - International Journal of …, 2014 - academic.oup.com
Post-traumatic stress disorder (PTSD) is increasingly recognized as both a disorder of
enormous mental health and societal burden, but also as an anxiety disorder that may be …

[HTML][HTML] Largest GWAS of PTSD (N= 20 070) yields genetic overlap with schizophrenia and sex differences in heritability

LE Duncan, A Ratanatharathorn, AE Aiello… - Molecular …, 2018 - nature.com
Abstract The Psychiatric Genomics Consortium-Posttraumatic Stress Disorder group (PGC-
PTSD) combined genome-wide case–control molecular genetic data across 11 multiethnic …

[HTML][HTML] International meta-analysis of PTSD genome-wide association studies identifies sex-and ancestry-specific genetic risk loci

CM Nievergelt, AX Maihofer, T Klengel… - Nature …, 2019 - nature.com
The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust
common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 …

[HTML][HTML] A DNA methylation biomarker of alcohol consumption

C Liu, RE Marioni, ÅK Hedman, L Pfeiffer, PC Tsai… - Molecular …, 2018 - nature.com
The lack of reliable measures of alcohol intake is a major obstacle to the diagnosis and
treatment of alcohol-related diseases. Epigenetic modifications such as DNA methylation …

[HTML][HTML] Methylation quantitative trait loci (meQTLs) are consistently detected across ancestry, developmental stage, and tissue type

AK Smith, V Kilaru, M Kocak, LM Almli, KB Mercer… - BMC genomics, 2014 - Springer
Background Individual genotypes at specific loci can result in different patterns of DNA
methylation. These methylation quantitative trait loci (meQTLs) influence methylation across …

Accounting for population stratification in DNA methylation studies

RT Barfield, LM Almli, V Kilaru, AK Smith… - Genetic …, 2014 - Wiley Online Library
ABSTRACT DNA methylation is an important epigenetic mechanism that has been linked to
complex diseases and is of great interest to researchers as a potential link between …

Association of CRP Genetic Variation and CRP Level With Elevated PTSD Symptoms and Physiological Responses in a Civilian Population With High Levels of …

V Michopoulos, AO Rothbaum… - American Journal of …, 2015 - Am Psychiatric Assoc
Objective: Increased systemic inflammation is associated with stress-related
psychopathology. Specifically, levels of the proinflammatory marker C-reactive protein …

Oxytocin receptor genetic and epigenetic variations: association with child abuse and adult psychiatric symptoms

EL Smearman, LM Almli, KN Conneely… - Child …, 2016 - Wiley Online Library
Childhood abuse can alter biological systems and increase risk for adult psychopathology.
Epigenetic mechanisms, alterations in DNA structure that regulate the gene expression, are …

[HTML][HTML] Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease

T Huan, R Joehanes, CI Song, F Peng, Y Guo… - Nature …, 2019 - nature.com
Identifying methylation quantitative trait loci (meQTLs) and integrating them with disease-
associated variants from genome-wide association studies (GWAS) may illuminate …

Epigenomic association analysis identifies smoking-related DNA methylation sites in African Americans

YV Sun, AK Smith, KN Conneely, Q Chang, W Li… - Human genetics, 2013 - Springer
Cigarette smoking is an environmental risk factor for many chronic diseases, and disease
risk can often be managed by smoking control. Smoking can induce cellular and molecular …