BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

K McArthur, LW Whitehead, JM Heddleston, L Li… - Science, 2018 - science.org
INTRODUCTION There has been an explosion of interest in the role of cell death pathways
and damage-associated molecular pattern (DAMP) signaling in shaping inflammatory and …

[HTML][HTML] MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

AL Samson, Y Zhang, ND Geoghegan, XJ Gavin… - Nature …, 2020 - nature.com
Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory
necroptotic cell death program. RIPK3-mediated phosphorylation is thought to initiate MLKL …

[HTML][HTML] DaXi—high-resolution, large imaging volume and multi-view single-objective light-sheet microscopy

B Yang, M Lange, A Millett-Sikking, X Zhao… - Nature …, 2022 - nature.com
The promise of single-objective light-sheet microscopy is to combine the convenience of
standard single-objective microscopes with the speed, coverage, resolution and gentleness …

[PDF][PDF] Essential role of the PfRh5/PfRipr/CyRPA complex during Plasmodium falciparum invasion of erythrocytes

JC Volz, A Yap, X Sisquella, JK Thompson, NTY Lim… - Cell host & …, 2016 - cell.com
Plasmodium falciparum parasites in the merozoite stage invade human erythrocytes and
cause malaria. Invasion requires multiple interactions between merozoite ligands and …

Occupational risk factors and asthma among health care professionals

GL Delclos, D Gimeno, AA Arif, KD Burau… - American Journal of …, 2007 - atsjournals.org
Rationale: Recent US data suggest an increased risk of work-related asthma among health
care workers, yet only a few specific determinants have been elucidated. Objectives: To …

[PDF][PDF] IL-18 production from the NLRP1 inflammasome prevents obesity and metabolic syndrome

AJ Murphy, MJ Kraakman, HL Kammoun, D Dragoljevic… - Cell metabolism, 2016 - cell.com
Summary Interleukin-18 (IL-18) is activated by Caspase-1 in inflammasome complexes and
has anti-obesity effects; however, it is not known which inflammasome regulates this …

Prevalence and risk factors of asthma and wheezing among US adults: an analysis of the NHANES III data

AA Arif, GL Delclos, ES Lee… - European …, 2003 - Eur Respiratory Soc
The prevalence of asthma has been on the increase in the USA and worldwide. To
understand the worsening epidemiological trends of asthma, this study analysed the data …

[HTML][HTML] Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites

BE Sleebs, S Lopaticki, DS Marapana, MT O'Neill… - PLoS …, 2014 - journals.plos.org
The malaria parasite Plasmodium falciparum exports several hundred proteins into the
infected erythrocyte that are involved in cellular remodeling and severe virulence. The …

Lensless imaging using broadband X-ray sources

B Abbey, LW Whitehead, HM Quiney, DJ Vine… - Nature …, 2011 - nature.com
High-resolution X-ray imaging techniques using optical elements such as zone plates are
widely used for viewing the internal structure of samples in exquisite detail. The resolution …

Diffractive imaging using partially coherent x rays

LW Whitehead, GJ Williams, HM Quiney, DJ Vine… - Physical review …, 2009 - APS
The measured spatial coherence characteristics of the illumination used in a diffractive
imaging experiment are incorporated in an algorithm that reconstructs the complex …