Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
Prostate cancer is a highly heritable disease with large disparities in incidence rates across
ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer …
ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer …
TMPRSS2:ERG Gene Fusions in Prostate Cancer of West African Men and a Meta-Analysis of Racial Differences
CK Zhou, D Young, ED Yeboah… - American journal of …, 2017 - academic.oup.com
The prevalence of fusions of the transmembrane protease, serine 2, gene (TMPRSS2) with
the erythroblast transformation-specific–related gene (ERG), or TMPRSS2: ERG, in prostate …
the erythroblast transformation-specific–related gene (ERG), or TMPRSS2: ERG, in prostate …
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
The transferability and clinical value of genetic risk scores (GRSs) across populations
remain limited due to an imbalance in genetic studies across ancestrally diverse …
remain limited due to an imbalance in genetic studies across ancestrally diverse …
Evidence of novel susceptibility variants for prostate cancer and a multiancestry polygenic risk score associated with aggressive disease in men of African ancestry
Background Genetic factors play an important role in prostate cancer (PCa) susceptibility.
Objective To discover common genetic variants contributing to the risk of PCa in men of …
Objective To discover common genetic variants contributing to the risk of PCa in men of …
[HTML][HTML] Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa
Background Genome-wide association studies do not always replicate well across
populations, limiting the generalizability of polygenic risk scores (PRS). Despite higher …
populations, limiting the generalizability of polygenic risk scores (PRS). Despite higher …
Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations
Background: We recently developed a multi-ancestry polygenic risk score (PRS) that
effectively stratifies prostate cancer risk across populations. In this study, we validated the …
effectively stratifies prostate cancer risk across populations. In this study, we validated the …
Evaluating approaches for constructing polygenic risk scores for prostate cancer in men of African and European ancestry
Genome-wide polygenic risk scores (GW-PRSs) have been reported to have better
predictive ability than PRSs based on genome-wide significance thresholds across …
predictive ability than PRSs based on genome-wide significance thresholds across …
[HTML][HTML] Circulating trans fatty acids are associated with prostate cancer in Ghanaian and American men
The association between fatty acids and prostate cancer remains poorly explored in African-
descent populations. Here, we analyze 24 circulating fatty acids in 2934 men, including …
descent populations. Here, we analyze 24 circulating fatty acids in 2934 men, including …
[HTML][HTML] Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the" endemic Burkitt Lymphoma belt"
Populations in sub-Saharan Africa have historically been exposed to intense selection from
chronic infection with falciparum malaria. Interestingly, populations with the highest malaria …
chronic infection with falciparum malaria. Interestingly, populations with the highest malaria …
[HTML][HTML] A rare germline HOXB13 variant contributes to risk of prostate cancer in men of African ancestry
A rare African ancestry–specific germline deletion variant in HOXB13 (X285K, rs77179853)
was recently reported in Martinican men with early-onset prostate cancer. Given the role of …
was recently reported in Martinican men with early-onset prostate cancer. Given the role of …