Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones
KH McClean, MK Winson, L Fish, A Taylor… - …, 1997 - microbiologyresearch.org
Quorum sensing relies upon the interaction of a diffusible signal molecule with a
transcriptional activator protein to couple gene expression with cell population density. In …
transcriptional activator protein to couple gene expression with cell population density. In …
The Connectivity Map: a new tool for biomedical research
J Lamb - Nature reviews cancer, 2007 - nature.com
The ultimate objective of biomedical research is to connect human diseases with the genes
that underlie them and drugs that treat them. But this remains a daunting task, and even the …
that underlie them and drugs that treat them. But this remains a daunting task, and even the …
Na+, K+-ATPase isozyme diversity; comparative biochemistry and physiological implications of novel functional interactions
Na+, K+-ATPase is ubiquitously expressed in the plasma membrane ofall animal cells
where it serves as the principal regulator of intracellularion homeostasis. Na+, K+-ATPase is …
where it serves as the principal regulator of intracellularion homeostasis. Na+, K+-ATPase is …
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease
J Lamb, ED Crawford, D Peck, JW Modell, IC Blat… - science, 2006 - science.org
To pursue a systematic approach to the discovery of functional connections among
diseases, genetic perturbation, and drug action, we have created the first installment of a …
diseases, genetic perturbation, and drug action, we have created the first installment of a …
MicroRNA expression profiles classify human cancers
Recent work has revealed the existence of a class of small non-coding RNA species, known
as microRNAs (miRNAs), which have critical functions across various biological processes …
as microRNAs (miRNAs), which have critical functions across various biological processes …
[HTML][HTML] A next generation connectivity map: L1000 platform and the first 1,000,000 profiles
…, J Rosains, DY Takeda, R Hu, D Davison, J Lamb… - Cell, 2017 - Elsevier
We previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs,
and disease states are connected by virtue of common gene-expression signatures. Here …
and disease states are connected by virtue of common gene-expression signatures. Here …
Functional impact of global rare copy number variation in autism spectrum disorders
The autism spectrum disorders (ASDs) are a group of conditions characterized by
impairments in reciprocal social interaction and communication, and the presence of …
impairments in reciprocal social interaction and communication, and the presence of …
Thermodynamic and kinetic data for cation-macrocycle interaction
RM Izatt, JS Bradshaw, SA Nielsen, JD Lamb… - Chemical …, 1985 - ACS Publications
Thermodynamic and kinetic data for cation-macrocycle interaction Page 1 Chem. Rev. 1985,
85. 271-339 271 Thermodynamic and Kinetic Data for Cation-Macrocycle Interaction1 REED …
85. 271-339 271 Thermodynamic and Kinetic Data for Cation-Macrocycle Interaction1 REED …
[HTML][HTML] Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease
The genetics of complex disease produce alterations in the molecular interactions of cellular
pathways whose collective effect may become clear through the organized structure of …
pathways whose collective effect may become clear through the organized structure of …
Genetics of gene expression surveyed in maize, mouse and man
EE Schadt, SA Monks, TA Drake, AJ Lusis, N Che… - Nature, 2003 - nature.com
Treating messenger RNA transcript abundances as quantitative traits and mapping gene
expression quantitative trait loci for these traits has been pursued in gene-specific ways …
expression quantitative trait loci for these traits has been pursued in gene-specific ways …