BACKGROUND: Airway inflammation is considered to be important in asthma but is
relatively inaccessible to study. Less invasive methods of obtaining sputum from patients …

Methods to examine sputum for indices of airway inflammation are evolving. We have
examined the repeatability and the validity of an improved method to measure sputum cells …

Non‐allergic bronchial hyper‐reactivity is a feature of most patients with asthma. We have
measured non‐allergic bronchial reactivity to inhaled histamine and methacholine in …

Sputum cell-counts were studied in 7 non-smokers with corticosteroid-responsive chronic
cough productive of sputum and 8 smokers with a clinical diagnosis of chronic bronchitis, all …

Consideration of the origin of airway hyperresponsiveness appears central to understanding
the origin of asthma. Subjects with and without asthma differ both in the ease with which …

A reliable predictor of benefit from corticosteroid treatment in patients with chronic airflow
limitation is needed. In a single-blind, sequential crossover trial of placebo and prednisone …

Sputum examination is being used increasingly as a noninvasive method to assess airway
inflammation. Expectorated sputum has variable contamination with saliva. Methods of …

• Seventeen patients, constituting 12.1% of 140 consecutively seen cases of chronic
urticaria, demonstrated thyroid autoimmunity with thyroid microsomal antibodies (TMAs) in …

Background: The objectives of the study were to evaluate impairment in quality of life in 12-
to 17-year-old patients with seasonal allergic rhinoconjunctivitis and to develop and test a …

We have investigated the time-course of symptoms, forced expiratory volume in one second
(FEV1), and the airway inflammatory changes in sputum selected from saliva and blood of …