[HTML][HTML] Cognitive outcomes caused by low-level lead, cadmium, and mercury mixture exposure at distinct phases of brain development

L Ouyang, Q Li, S Rao, R Su, Y Zhu, G Du, J Xie… - Food and Chemical …, 2023 - Elsevier
Contaminated water and food are the main sources of lead, cadmium, and mercury in the
human body. Long-term and low-level ingestion of these toxic heavy metals may affect brain …

Metabolic reprogramming of glycolysis favors cartilage progenitor cells rejuvenation: a potential therapeutic for Osteoarthritis

J Shi, G Du - Joint Bone Spine, 2023 - Elsevier
Osteoarthritis (OA), the leading cause of disability in the elderly, still lacks effective treatment
due to the unelucidated mechanisms of pathogenesis and progression. In cartilage …

The effect of lead exposure on brain iron homeostasis and the expression of DMT1/FP1 in the brain in developing and aged rats

G Zhu, G Fan, C Feng, Y Li, Y Chen, F Zhou, G Du… - Toxicology letters, 2013 - Elsevier
The relation between lead (Pb) and iron (Fe) becomes increasingly concerned because they
are both divalent metals that are absorbed by the same intestinal mechanism, and Pb …

RyRs mediate lead-induced neurodegenerative disorders through calcium signaling pathways

F Zhou, G Du, J Xie, J Gu, Q Jia, Y Fan, H Yu… - Science of the total …, 2020 - Elsevier
Heavy metal lead (Pb) is widely distributed in the environment and can induce
neurodegeneration. Accumulating evidence has shown that ryanodine receptors (RyRs) …

Oxidative stress in the neurodegenerative brain following lifetime exposure to lead in rats: Changes in lifespan profiles

C Feng, S Liu, F Zhou, Y Gao, Y Li, G Du, Y Chen… - Toxicology, 2019 - Elsevier
A large number of studies have evidenced that developmental neurotoxicity induced by lead
(Pb) is related to oxidative injury. Furthermore, recent studies have found that developmental …

The effect of lead exposure on expression of SIRT1 in the rat hippocampus

C Feng, J Gu, F Zhou, J Li, G Zhu, L Guan, H Liu… - Environmental …, 2016 - Elsevier
Based on how the silent information regulator 2 homolog 1 (SIRT1) regulates the cyclic AMP
response element binding protein (CREB), which is the molecular switch of long-term …

[HTML][HTML] The glial cell-derived neurotrophic factor (GDNF)-responsive phosphoprotein landscape identifies raptor phosphorylation required for spermatogonial …

M Wang, Y Guo, M Wang, T Zhou, Y Xue, G Du… - Molecular & Cellular …, 2017 - ASBMB
Cytokine-dependent renewal of stem cells is a fundamental requisite for tissue homeostasis
and regeneration. Spermatogonial progenitor cells (SPCs) including stem cells support life …

Pregnancy and lactation mixed exposure to lead, cadmium, and mercury alters maternal-offspring single heavy metal load: A factorial design

G Du, F Zhou, L Ouyang, K Wang, S Rao, R Su… - International Journal of …, 2023 - Elsevier
Environmental exposure to heavy metal mixture of lead (Pb), cadmium (Cd), and mercury
(Hg) would induce hazardous health effects. However, there is a paucity of data on how …

Proper timing of a quiescence period in precursor prospermatogonia is required for stem cell pool establishment in the male germline

G Du, MJ Oatley, NC Law, C Robbins, X Wu… - …, 2021 - journals.biologists.com
The stem cell-containing undifferentiated spermatogonial population in mammals, which
ensures continual sperm production, arises during development from prospermatogonial …

Hippocampal LIMK1-mediated Structural Synaptic Plasticity in Neurobehavioral Deficits Induced by a Low-dose Heavy Metal Mixture

F Zhou, L Ouyang, Q Li, S Yang, S Liu, H Yu, Q Jia… - Molecular …, 2023 - Springer
Humans are commonly exposed to the representative neurotoxic heavy metals lead (Pb),
cadmium (Cd), and mercury (Hg). These three substances can be detected simultaneously …