Mitochondrial-targeted plastoquinone derivatives. Effect on senescence and acute age-related pathologies

MV Skulachev, YN Antonenko… - Current drug …, 2011 - ingentaconnect.com
Plastoquinone, a very effective electron carrier and antioxidant of chloroplasts, was
conjugated with decyltriphenylphosphonium to obtain a cation easily penetrating through …

[HTML][HTML] Guidelines and recommendations on yeast cell death nomenclature

D Carmona-Gutierrez, MA Bauer, A Zimmermann… - Microbial Cell, 2018 - ncbi.nlm.nih.gov
Elucidating the biology of yeast in its full complexity has major implications for science,
medicine and industry. One of the most critical processes determining yeast life and …

[HTML][HTML] Prevention of cardiolipin oxidation and fatty acid cycling as two antioxidant mechanisms of cationic derivatives of plastoquinone (SkQs)

VP Skulachev, YN Antonenko, DA Cherepanov… - … et Biophysica Acta (BBA …, 2010 - Elsevier
The present state of the art in studies on the mechanisms of antioxidant activities of
mitochondria-targeted cationic plastoquinone derivatives (SkQs) is reviewed. Our …

The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast

S Biggins, FF Severin, N Bhalla, I Sassoon… - Genes & …, 1999 - genesdev.cshlp.org
Chromosome segregation depends on kinetochores, the structures that mediate
chromosome attachment to the mitotic spindle. We isolated mutants in IPL1, which encodes …

Rab5 regulates motility of early endosomes on microtubules

E Nielsen, F Severin, JM Backer, AA Hyman… - Nature cell …, 1999 - nature.com
Abstract The small GTPase Rab5 regulates membrane docking and fusion in the early
endocytic pathway. Here we reveal a new role for Rab5 in the regulation of endosome …

CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex

…, G Lansbergen, H Sasaki, C Matsui, F Severin… - The Journal of cell …, 2005 - rupress.org
CLIP-associating protein (CLASP) 1 and CLASP2 are mammalian microtubule (MT) plus-
end binding proteins, which associate with CLIP-170 and CLIP-115. Using RNA interference …

Role of mitochondria in the pheromone-and amiodarone-induced programmed death of yeast

AI Pozniakovsky, DA Knorre, OV Markova… - The Journal of cell …, 2005 - rupress.org
Although programmed cell death (PCD) is extensively studied in multicellular organisms, in
recent years it has been shown that a unicellular organism, yeast Saccharomyces …

[PDF][PDF] Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B

S Hoepfner, F Severin, A Cabezas, B Habermann… - Cell, 2005 - cell.com
Different classes of endosomes exhibit a characteristic intracellular steady-state distribution
governed by interactions with the cytoskeleton. We found a kinesin-3, KIF16B, that transports …

Penetrating cation/fatty acid anion pair as a mitochondria-targeted protonophore

FF Severin, II Severina, YN Antonenko… - Proceedings of the …, 2010 - National Acad Sciences
A unique phenomenon of mitochondria-targeted protonophores is described. It consists in a
transmembrane H+-conducting fatty acid cycling mediated by penetrating cations such as 10 …

Molecular requirements for bi-directional movement of phagosomes along microtubules

A Blocker, FF Severin, JK Burkhardt… - The Journal of cell …, 1997 - rupress.org
Microtubules facilitate the maturation of phagosomes by favoring their interactions with
endocytic compartments. Here, we show that phagosomes move within cells along tracks of …