Osteoarthritis (OA) is the most common musculoskeletal disease, affecting millions of
individuals worldwide. New treatment approaches require an understanding of the …

Iron dysregulation has been implicated in multiple neurodegenerative diseases, including
Parkinson's disease (PD). Iron-loaded microglia are frequently found in affected brain …

BACKGROUND: Variability in patient care settings and the range of patient handling tasks
present challenges in developing and evaluating safe patient handling and mobilization …

Objective To investigate whether cartilage degeneration is prevented or minimized following
intraarticular injections of lubricin derived from human synoviocytes in culture, recombinant …

Background: Lubricin and hyaluronic acid lubricate articular cartilage and prevent wear.
Because lubricin loss occurs after anterior cruciate ligament injury, intra-articular lubricin …

The coefficient of friction (COF) of articular cartilage is thought to increase with osteoarthritis
(OA) progression, and this increase may occur due to a decrease in lubricin concentration …

Objective To investigate whether cartilage degeneration is prevented or minimized in a rat
model of anterior cruciate ligament (ACL) injury following a single dose‐escalated …

The objective was to compare biomarkers of articular cartilage metabolism in synovial fluid
from Hartley guinea pig knees, with and without anterior cruciate ligament transection …

Background: Lubricin, or proteoglycan 4 (PRG4), is a glycoprotein responsible for joint
boundary lubrication. PRG4 has been shown previously to be down-regulated after …

Background: Neuronopathic Gaucher disease (nGD) is a rare neurodegenerative disorder
caused by biallelic mutations in GBA and buildup of glycosphingolipids in lysosomes …