The toxicology of perfluorooctanoate

GL Kennedy, JL Butenhoff, GW Olsen… - Critical reviews in …, 2004 - Taylor & Francis
ABSTRACT PFOA is a peroxisome proliferator (PPAR agonist) and exerts morphological
and biochemical effects characteristic of PPAR agonists. These effects include increased β …

Perfluoroalkyl acids and related chemistries—toxicokinetics and modes of action

ME Andersen, JL Butenhoff, SC Chang… - Toxicological …, 2008 - academic.oup.com
The perfluoroalkyl acid salts (both carboxylates and sulfonates, hereafter designated as
PFAAs) and their derivatives are important chemicals that have numerous consumer and …

Hepatocellular hypertrophy and cell proliferation in Sprague–Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased …

CR Elcombe, BM Elcombe, JR Foster, DG Farrar… - Archives of …, 2010 - Springer
Ammonium perfluorooctanoate (APFO), a processing aid used in the production of
fluoropolymers, produces hepatomegaly and hepatocellular hypertrophy in rodents. In mice …

Penetration of ammonium perfluorooctanoate through rat and human skin in vitro

WJ Fasano, GL Kennedy, B Szostek… - Drug and chemical …, 2005 - Taylor & Francis
Rat and human epidermal membranes were mounted onto in vitro diffusion cells with an
exposure area of 0.64 cm2, and skin integrity was confirmed using electrical impedance …

Acute and chronic aquatic toxicity of ammonium perfluorooctanoate (APFO) to freshwater organisms

I Colombo, W de Wolf, RS Thompson, DG Farrar… - Ecotoxicology and …, 2008 - Elsevier
Recent concerns have been raised concerning the widespread distribution of perfluorinated
compounds in environmental matrices and biota. The compounds of interest include …

Cancer risk among tetrafluoroethylene synthesis and polymerization workers

D Consonni, K Straif, JM Symons… - American journal of …, 2013 - academic.oup.com
Tetrafluoroethylene (TFE), a compound used for the production of fluorinated polymers
including polytetrafluoroethylene, increases the incidence of liver and kidney cancers and …

π-Back-bonding in Bis (isonitrile) complexes of rhodium (II) acetate: structural analogs for rhodium carbenoids

CT Eagle, DG Farrar, CU Pfaff, JA Davies… - …, 1998 - ACS Publications
Rh2 (O2CCH3) 4⊙ 2C⋮ NC6H4R (R=(CH3) 2N−(1),− H (2),− CF3 (3)) were synthesized
and characterized by X-ray crystallography. The structures exhibited several common …

Health risk assessment of environmental exposure to trichloroethylene

LP Brown, DG Farrar, CG de Rooij - Regulatory Toxicology and …, 1990 - Elsevier
A review of the animal data showed trichloroethylene (TRI) to be of low acute toxicity.
Repeated exposure showed that the target organs were the liver and, to a lesser extent, the …

Antagonism of tone and prostaglandin-mediated responses in a tracheal preparation by indomethacin and SC-19220

JB Farmer, DG Farrar, J Wilson - British Journal of Pharmacology, 1974 - ncbi.nlm.nih.gov
Abstract 1 The effects of the prostaglandin synthetase inhibitor, indomethacin and the
prostaglandin antagonist SC-19220 (1-acetyl-2-[8-chloro-10, 11-dihydrodibenz (b, f)(1, 4) …

Pharmacological studies with adenine, adenosine and some phosphorylated derivatives on guinea-pig tracheal muscle

JB Farmer, DG Farrar - Journal of Pharmacy and Pharmacology, 1976 - academic.oup.com
Adenine, adenosine and three adenine nucleotides all caused relaxation of the guinea-pig
trachea. The relaxation to the nucleotides was often preceded by a contraction. The …