Human serum paraoxonase is located on an HDL. It has the capacity to retard the
accumulation of lipid peroxides in LDL under oxidizing conditions in vitro. Paraoxonase has …

Human serum paraoxonase (PON1) is a Ca 2+-dependent 45-kDa glycoprotein that is
associated with high density lipoprotein (HDL). 2. PON1 hydrolyzes organophosphate (OP) …

Human PON1 is a HDL-associated lipolactonase capable of preventing LDL and cell
membrane oxidation and is therefore considered to be atheroprotective. PON1 contributes to …

Human serum paraoxonase (PON1) hydrolyzes oxidized lipids in low density lipoprotein
(LDL) and could therefore retard the development of atherosclerosis. In keeping with this …

Background—The hypothesis that paraoxonase (PON1) has a role in preventing
atherosclerosis is based on experimental, transgenic, and case-control studies but has not …

Human serum paraoxonase (PON1) associated with high density lipoprotein (HDL) has
been postulated to have a role in protecting low density lipoprotein (LDL) against oxidative …

HDL has been shown to prevent the oxidative modification of LDL. The antioxidant activity of
HDL is believed to reside in its enzymes, particularly paraoxonase. Human serum …

Human serum paraoxonase (PON1) is located on high density lipoprotein and has been
implicated in the detoxification of organophosphates and possibly in the prevention of low …

Paraoxonase (PON1) hydrolyses organophosphate insecticides and nerve gases and is
responsible for determining the selective toxicity of these compounds in mammals. Human …

The antioxidant activity of HDL is largely due to the paraoxonase (PON1) located on it.
Experiments with transgenic PON1 knock-out mice indicate the potential for PON1 to protect …