User profiles for "author:Asim Saha"
Asim Saha, Ph.D.Senior Research Scientist, University of Minnesota Verified email at umn.edu Cited by 2192 |
Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade
The recent successes of immunotherapy have shifted the paradigm in cancer treatment, but
because only a percentage of patients are responsive to immunotherapy, it is imperative to …
because only a percentage of patients are responsive to immunotherapy, it is imperative to …
[HTML][HTML] Luteolin, an abundant dietary component is a potent anti-leishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage …
Background Plant-derived flavonoids, which occur abundantly in our daily dietary intake,
possess antitumor, antibacterial, and free radical scavenging properties. They form active …
possess antitumor, antibacterial, and free radical scavenging properties. They form active …
Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality
A Saha, K Aoyama, PA Taylor… - Blood, The Journal …, 2013 - ashpublications.org
Abstract Programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, play an important
role in the maintenance of peripheral tolerance. We explored the role of PD-1 ligands in …
role in the maintenance of peripheral tolerance. We explored the role of PD-1 ligands in …
[HTML][HTML] Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality
A Saha, RS O'Connor, G Thangavelu… - The Journal of …, 2016 - Am Soc Clin Investig
Programmed death ligand-1 (PD-L1) interaction with PD-1 induces T cell exhaustion and is
a therapeutic target to enhance immune responses against cancer and chronic infections. In …
a therapeutic target to enhance immune responses against cancer and chronic infections. In …
B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality
RG Veenstra, R Flynn, K Kreymborg… - Blood, The Journal …, 2015 - ashpublications.org
Members of the B7 family have been shown to be important for regulating immune
responses by providing either positive or negative costimulatory signals. The function of B7 …
responses by providing either positive or negative costimulatory signals. The function of B7 …
Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD
Myeloid-derived suppressor cells (MDSCs) can subdue inflammation. In mice with acute
graft-versus-host disease (GVHD), donor MDSC infusion enhances survival that is only …
graft-versus-host disease (GVHD), donor MDSC infusion enhances survival that is only …
A CD45-targeted antibody-drug conjugate successfully conditions for allogeneic hematopoietic stem cell transplantation in mice
A Saha, S Hyzy, T Lamothe… - Blood, The Journal …, 2022 - ashpublications.org
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative
treatment of patients with nonmalignant or malignant blood disorders. Its success has been …
treatment of patients with nonmalignant or malignant blood disorders. Its success has been …
Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration
Graft-versus-host disease (GVHD) is a critical complication after allogeneic bone marrow
transplantation. During GVHD, donor T cells are activated by host antigen-presenting cells …
transplantation. During GVHD, donor T cells are activated by host antigen-presenting cells …
[HTML][HTML] Pulmonary function and fuel use: a population survey
A Saha, N Mohan Rao, PK Kulkarni, PK Majumdar… - Respiratory …, 2005 - Springer
Background In the backdrop of conflicting reports (some studies reported adverse outcomes
of biomass fuel use whereas few studies reported absence of any association between …
of biomass fuel use whereas few studies reported absence of any association between …
Combination of CTL‐associated Antigen‐4 Blockade and Depletion of CD25+ Regulatory T Cells Enhance Tumour Immunity of Dendritic Cell‐based Vaccine in a …
A Saha, SK Chatterjee - Scandinavian journal of immunology, 2010 - Wiley Online Library
Immune regulation has been shown to be involved in the progressive growth of some
murine tumours. Interruption of immune regulatory pathways via CTL‐associated antigen‐4 …
murine tumours. Interruption of immune regulatory pathways via CTL‐associated antigen‐4 …