User profiles for "author:Asim Saha"

Asim Saha, Ph.D.

Senior Research Scientist, University of Minnesota
Verified email at umn.edu
Cited by 2192

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

Z Wang, EG Aguilar, JI Luna, C Dunai, LT Khuat… - Nature medicine, 2019 - nature.com
The recent successes of immunotherapy have shifted the paradigm in cancer treatment, but
because only a percentage of patients are responsive to immunotherapy, it is imperative to …

[HTML][HTML] Luteolin, an abundant dietary component is a potent anti-leishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage …

B Mittra, A Saha, A Roy Chowdhury, C Pal, S Mandal… - Molecular …, 2000 - Springer
Background Plant-derived flavonoids, which occur abundantly in our daily dietary intake,
possess antitumor, antibacterial, and free radical scavenging properties. They form active …

Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality

A Saha, K Aoyama, PA Taylor… - Blood, The Journal …, 2013 - ashpublications.org
Abstract Programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, play an important
role in the maintenance of peripheral tolerance. We explored the role of PD-1 ligands in …

[HTML][HTML] Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality

A Saha, RS O'Connor, G Thangavelu… - The Journal of …, 2016 - Am Soc Clin Investig
Programmed death ligand-1 (PD-L1) interaction with PD-1 induces T cell exhaustion and is
a therapeutic target to enhance immune responses against cancer and chronic infections. In …

B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality

RG Veenstra, R Flynn, K Kreymborg… - Blood, The Journal …, 2015 - ashpublications.org
Members of the B7 family have been shown to be important for regulating immune
responses by providing either positive or negative costimulatory signals. The function of B7 …

Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD

BH Koehn, A Saha, C McDonald-Hyman… - Blood, The Journal …, 2019 - ashpublications.org
Myeloid-derived suppressor cells (MDSCs) can subdue inflammation. In mice with acute
graft-versus-host disease (GVHD), donor MDSC infusion enhances survival that is only …

A CD45-targeted antibody-drug conjugate successfully conditions for allogeneic hematopoietic stem cell transplantation in mice

A Saha, S Hyzy, T Lamothe… - Blood, The Journal …, 2022 - ashpublications.org
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative
treatment of patients with nonmalignant or malignant blood disorders. Its success has been …

Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration

K Aoyama, A Saha, J Tolar, MJ Riddle… - Blood, The Journal …, 2013 - ashpublications.org
Graft-versus-host disease (GVHD) is a critical complication after allogeneic bone marrow
transplantation. During GVHD, donor T cells are activated by host antigen-presenting cells …

[HTML][HTML] Pulmonary function and fuel use: a population survey

A Saha, N Mohan Rao, PK Kulkarni, PK Majumdar… - Respiratory …, 2005 - Springer
Background In the backdrop of conflicting reports (some studies reported adverse outcomes
of biomass fuel use whereas few studies reported absence of any association between …

Combination of CTL‐associated Antigen‐4 Blockade and Depletion of CD25+ Regulatory T Cells Enhance Tumour Immunity of Dendritic Cell‐based Vaccine in a …

A Saha, SK Chatterjee - Scandinavian journal of immunology, 2010 - Wiley Online Library
Immune regulation has been shown to be involved in the progressive growth of some
murine tumours. Interruption of immune regulatory pathways via CTL‐associated antigen‐4 …