This study examined work/non-work conflict and subjective health among female shift workers. Questionnaire data from 172 nurses were used to examine the effects of family status [single (S), living with partner (P), and living with partner and children (P + C)] and social support (from supervisors, co-workers, and family) on work/non-work conflict and health. Results indicated that work/non-work conflict was positively related to family status and negatively related to supervisor support. Psychological symptoms were related positively to work/non-work conflict and negatively to family support. Physical symptoms were related positively to work/ non-work conflict and negatively to co-worker and family support. Time-budget data from 24 nurses indicated that the P + C group spent more time on domestic work than the S and P groups and less time on leisure than the S group. Data collected from eight couples indicated that the nurses recorded more domestic work and less leisure than their male partners. The results indicate that work/non-work conflict is particularly salient for female shift workers living with a partner and dependent children, and highlight the importance of social support for this group of shift workers.