The extraordinary increase in latex glove use in dentistry within the past decade has created a potential occupational hazard in the form of adverse reactions to components found in these gloves. Reactions may range from dry, itchy skin to a life-threatening, anaphylactic response. Management of these conditions may be as simple as switching glove brands; but in the most severe cases, it may entail the need to create a latex-free environment for the safety of the affected health care worker. This article reviews the pathophysiology, epidemiology, diagnosis and management of these conditions and provides references for more in-depth reading on the subject.