Abstract
A number of cases of infertility were discovered among men working in a California pesticide factory. The suspected cause was exposure to the chemical 1,2-dibromo-3-chloropropane (D.B.C.P.). The major effects, seen in 14 of 25 non-vasectomised men, were azoospermia or oligospermia and raised serum-levels of follicle-stimulating hormone and luteinising hormone. No other major abnormalities were detected, and testosterone levels were normal. Although a quantitative estimation of exposure could not be obtained, the observed effects appeared to be related to duration of exposure to D.B.C.P.
MeSH terms
-
Adult
-
Antinematodal Agents / adverse effects*
-
California
-
Cell Count
-
Chemical Industry
-
Follicle Stimulating Hormone / blood
-
Humans
-
Hydrocarbons, Halogenated / adverse effects*
-
Infertility, Male / chemically induced*
-
Infertility, Male / diagnosis
-
Luteinizing Hormone / blood
-
Male
-
Occupational Diseases / chemically induced*
-
Oligospermia / chemically induced
-
Oligospermia / pathology
-
Propane / adverse effects
-
Propane / analogs & derivatives*
-
Spermatozoa / pathology
-
Testosterone / blood
Substances
-
Antinematodal Agents
-
Hydrocarbons, Halogenated
-
Testosterone
-
Luteinizing Hormone
-
Follicle Stimulating Hormone
-
1,2-dibromo-3-chloropropane
-
Propane