This study identifies the relative importance of psychological dimensions that discriminate between habitually physically active and sedentary men. The data support the notion that physical activity has psychological benefits. Subjects (N = 22) were normal, medically healthy middle-aged men (40-60 years of age). Data were collected on selected physiological (treadmill) and psychological (MMPI) variables and replicated within four months. The Student's t-test and discriminant function analysis were used in the statistical analysis. Physically active men (n = 11) have lower depression (scale 2) and lower social introversion (scale 10) than the sedentary men (n = 11). The physically active men may exhibit MMPI scale differences in 'neurotic' tendencies from the sedentary men, but there is no apparent difference in scales suggestive of 'psychotic' tendencies. Depression (scale 2) is the most powerful discriminator between physically active and sedentary men, followed by hysteria (scale 3) and social introversion (scale 10). In conclusion, our data identify depression as the most important MMPI scale that discriminates between physically active and sedentary men.