Incidence of peripheral neuropathy and cerebellar ataxia in chronic alcoholics

J Neurol. 1986 Aug;233(4):212-7. doi: 10.1007/BF00314021.

Abstract

A total of 78 chronic alcoholics were examined neurologically as well as by electroneurography, myography and posturography. Clinical signs of peripheral neuropathy were detected in 45% of these patients, with electromyographic and neurographic abnormality in 67% and 55% respectively. Clinical signs of cerebellar ataxia were found in 33% of our patients, whereas posturographic measurements of increased sway were recorded in 69%. The posturographic characteristics of cerebellar anterior lobe atrophy were observed in two-thirds of the latter patients. The severity of cerebellar-ataxia did not correlate with the degree of neuropathy. This lack of correlation is interpreted as an indication of different pathogenetic mechanisms acting on peripheral nerves and cerebellum.

MeSH terms

  • Adult
  • Afferent Pathways / physiopathology
  • Aged
  • Alcoholism / physiopathology*
  • Axons / physiology
  • Cerebellar Ataxia / physiopathology*
  • Electromyography
  • Female
  • Gait
  • H-Reflex
  • Humans
  • Male
  • Middle Aged
  • Muscles / innervation
  • Myelin Sheath / physiology
  • Nerve Degeneration
  • Peripheral Nervous System Diseases / physiopathology*
  • Posture
  • Proprioception
  • Spinal Cord / physiopathology
  • Tibial Nerve / physiopathology