The role of the private sector in funding academic research is increasing and the well-developed guidelines for government-sponsored research do not apply to the academic-industry arena. Good Practice Guidelines for privately funded occupational health research are necessary. Industry sponsors and academic researchers belong to differing systems with differing goals and means to achieve and evaluate them. As a result, problems are inherent in the relationship. Guidelines would benefit industry by providing criteria against which industry-funded research could be judged and evaluated. Guidelines would help university researchers assure that their work is examined and criticized on its merits. Such protection would foster quality research over the long term. Here, we consider the issues involved and explore questions that came out of a workshop convened under the auspices of the Centers for Disease Control and Prevention. When private funding is involved, university scientists have a professional responsibility to ensure that the integrity of researchers, subjects, and the research process is well protected. A body of experience allows us to create Good Practice Guidelines beneficial to all parties.