Associations between exposure to polycyclic aromatic hydrocarbons and temporal change of urinary 1-hydroxypyrene levels in Taiwanese coke-oven workers

J Occup Environ Med. 2006 Sep;48(9):930-6. doi: 10.1097/01.jom.0000226974.91335.5b.

Abstract

Objectives: Our aim is to analyze the association between polycyclic aromatic hydrocarbon (PAH) exposure and the temporal change of urinary 1-hydroxypyrene (1-OHP).

Methods: Two personal air samples, eight spot urine samples, and questionnaires were used to collect PAH exposure, urinary 1-OHP, demographic data, and environmental pollutants.

Results: Topside-oven workers had significantly higher levels of PAH exposure and 1-OHP than side-oven workers. Urinary 1-OHP was a biomarker for PAH exposure. In topside-oven workers, the trend of 1-OHP increased sharply and reached the top in the sixth day after work and declined dramatically on days off. In side-oven workers, such a trend was not found, and those who smoked showed a slight increase in urinary 1-OHP levels on days off.

Conclusions: We suggest that the pattern of temporal change of urinary 1-OHP levels is different between topside-oven and side-oven workers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Air Pollutants, Occupational / analysis*
  • Coke*
  • Humans
  • Linear Models
  • Male
  • Occupational Exposure
  • Polycyclic Aromatic Hydrocarbons / analysis*
  • Pyrenes / metabolism*
  • Taiwan

Substances

  • Air Pollutants, Occupational
  • Coke
  • Polycyclic Aromatic Hydrocarbons
  • Pyrenes
  • 1-hydroxypyrene