Using the results of psychophysical and biomechanical experiments, NIOSH (National Institute for Occupational Safety and Health) Recommended Weight Limit (RWL), the Lifting Index (LI), the form of the asymmetry multiplier, and the criterion for compression force were investigated. Analysis of the results indicated a significant difference between the NIOSH RWL and the reported Maximum Acceptable Weight of Lift (MAWL). Contrary to the NIOSH lifting equation, the form of the asymmetry multiplier was found to be non-linear. The overall average of peak compression force on the L5/S1 was 3685 N. Fifty-eight percent of all compression forces reported in the biomechanical experiment were found to exceed the suggested 3400 N set by NIOSH guidelines. These results support previous research findings on the validity of NIOSH guidelines.