Chest
Laboratory and Animal InvestigationsEffect of Erionite on the Pleural Mesothelium of the Fischer 344 Rat
Section snippets
Fiber Evaluation
The erionite fibers were characterized by suspending random samples in distilled water and collecting them on a 0.2-μm polycarbonate filter. Next, the filter surface and its adherent erionite fibers were coated with evaporated carbon, and extraction replicas were made by dissolving the filter matrix in chloroform. The replicas were analyzed at a magnification of ×9,400 using an image analysis system (EDAX NX-2; EDAX Intl;
Mahwah, NJ) interfaced to an electron microscope (JEOL 100 CX, JEOL Ltd;
RESULTS
Pleural fibrosis, often accompanied by adhesive bands to the chest wall, was prominent and was found in 9 of 21 cases (Fig 3). Foreign body granuloma were found in 6 of the 21 cases and often included multinucleated giant cells. The single mesothelioma developing in this series had a gross multinodular appearance and extended to the diaphragmatic surface. This fibrosarcomatous mesothelioma was invasive and extended down from the pleura into the underlying lung tissue (Fig 4). Although diagnosed
DISCUSSION
Erionite, a fibrous zeolite (hydrated aluminum silicate), has a strong carcinogenic potential in humans.
Artvinli and Baris5 determined the prevalence of pleural mesothelioma in the Turkish Anatolian village of Tuzkoy, well known for its erionite-rich soil. Kizilkoy, a village 12 km away, was used as control village. Sixty-seven deaths were recorded in Tuzkoy over a period of 3 years, and of these, 41 were attributed to malignancies. Fifteen of these 41 malignancies were mesotheliomas. There
ACKNOWLEDGMENT
The authors are grateful to Karen Ginese for her assistance with the preparation of the manuscript.
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Funded by Baylor Grant BRSG 520-G16261 and by the Baylor Pulmonary Pathology Research Grant, Baylor College of Medicine, Houston.