Elevated birth defects in racial or ethnic minority children of women living near hazardous waste sites

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Abstract

This case-control study evaluated the relationship between birth defects in racial or ethnic minority children born during 1983 – 1988 and the potential exposure of their mothers to contaminants at hazardous waste sites in California. Four categories of race or ethnicity were used: black/African American, Hispanic/Latino, American Indian/Alaska Native, and Asian/ Pacific Islander. Case subjects were 13,938 minority infants with major structural birth defects (identified by the California Birth Defects Monitoring Program) whose mothers resided in selected counties at the time of delivery. The control group was composed of 14,463 minority infants without birth defects who were randomly selected from the same birth cohort as the case subjects. The potential for exposure was determined by whether the mother resided at the time of delivery in the same census tract as a hazardous waste site that was on the U.S. Environmental Protection Agency's National Priorities List (NPL). Racial/ethnic minority infants whose mothers had been potentially exposed to hazardous waste were at slightly increased risk for birth defects (odds ratio [OR]=1.12, 95% confidence interval [CI]=0.98 – 1.27) than were racial/ethnic minority infants whose mothers had not been potentially exposed. The greatest association was between potential exposure and neural tube defects (OR=1.54, 95% CI=0.93 – 2.55), particularly anencephaly (OR=1.85, 95% CI=0.91 – 3.75). The strongest association between birth defects and potential exposure was among American Indians/Alaska Natives (OR=1.19, 95% CI=0.62 – 2.27). Despite the limitations of this study, the consistency of these findings with previous studies suggests an association between environmental risk factors and birth defects. This is particularly relevant to minority populations. We recommend further investigation of birth defects among minority communities, particularly among American Indians/Alaska Natives. Special attention should also be paid to those defects and contaminants that consistently are associated with exposure to hazardous waste.

References (22)

  • Agency for Toxic Substances and Disease Registry: Birth defects among children of racial or ethnic minorities born to...
  • Agency for Toxic Substances and Disease Registry: The occurrence of neural tube, heart, and oral cleft defects in areas...
  • B. Baden et al.

    The locality of waste sites within the City of Chicago: A demographic, social and economic analysis

    (1997)
  • Centers for Disease Control and Prevention. Temporal trends in the incidence of birth defects-United States. MMWR...
  • Centers for Disease Control and Prevention. Trends in infant mortality attributable to birth defects-United States,...
  • Commission for Racial Justice, United Church of Christ. Toxic wastes and race in the United States: A national report...
  • K. Copeland et al.

    Bias due to misclassification in the estimation of relative risk

    Am. J. Epidemiol.

    (1977)
  • L. Croen et al.

    Birth defects monitoring in California: A resource for epidemiological research

    Paediatri. Perinat. Epidemiol.

    (1991)
  • L. Croen et al.

    Maternal residential proximity to hazardous waste sites and risk for selected congenital malformations

    Epidemiology

    (1997)
  • M. Dorsch et al.

    Congenital malformations and maternal drinking water supply in rural South Australia: A case-control study

    Am. J. Epidemiol.

    (1984)
  • P. Elliot et al.

    Risk of adverse birth outcomes in populations living near landfill sites

    Br. Med. J.

    (2001)
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