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Infant leukaemia after in utero exposure to radiation from Chernobyl

Abstract

THERE has been no documented increase in childhood leukaemia following the Chernobyl accident. However, different forms of childhood leukaemia may not be equally susceptible to radiation carcinogenesis. Infant leukaemia is a distinct form associated with a specific genetic abnormality. Outside the former Soviet Union, contamination resulting from the Chernobyl accident has been highest in Greece and Austria and high also in the Scandinavian countries1–4. All childhood leukaemia cases diagnosed throughout Greece since 1 January 1980 have been recorded. Here we report that infants exposed in utero to ionizing radiation from the Chernobyl accident had 2.6 times the incidence of leukaemia compared to unexposed children (95% confidence interval, 1.4 to 5.1; P ≈ 0.003), and those born to mothers residing in regions with high radioactive fallout were at higher risk of developing infant leukaemia. No significant difference in leukaemia incidence was found among children aged 12 to 47 months. Preconceptional irradiation had no demonstrable effect on leukaemia risk at any of the studied age groups.

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References

  1. Papastephanou, C., Manolopoulou, M. & Charalambous, S. J. Envir. Radioact. 7, 49–64 (1988).

    Article  Google Scholar 

  2. Auvinen, A. et al. Br. med. J. 309, 151–154 (1994).

    Article  CAS  Google Scholar 

  3. International Chernobyl Project Technical Rep. (IAEA report number: ISBN 92-0-129191-4, Vienna, 1992)

  4. Petridou, E. et al. Scand. J. Soc. Med. 22, 127–131 (1994).

    Article  CAS  Google Scholar 

  5. Abelin, T. et al. Soz. Präventivmed. 39, 189–197 (1994).

    Article  CAS  Google Scholar 

  6. Kuchuk, A. A. Tox. Lett. 72, 213–217 (1994).

    Article  CAS  Google Scholar 

  7. Vanchieri, C. J. natn. Cancer Inst. 84, 1616 (1992).

    Article  CAS  Google Scholar 

  8. Hjalmars, U., Kulldorff, M. & Gustafsson, G. Br. med. J. 309, 154–157 (1994).

    Article  CAS  Google Scholar 

  9. Parkin, D. M. et al. Euro. J. Cancer 29, A87–95 (1992).

    Article  Google Scholar 

  10. Cimino, G. Blood 82, 544–546 (1993).

    CAS  PubMed  Google Scholar 

  11. Cortes, J. E. & Kantarjian, H. M. Cancer 76, 2393–2416 (1995).

    Article  CAS  Google Scholar 

  12. U.S. National Academy of Sciences Committee on Biological Effects of Ionizing Radiation. BEIR-V Rep. (U.S. N.A.S. Washington, 1990).

  13. Hoshimoto, Y., Kato, H. & Schull, W. J. RERF Technical Report 4–88 (Radiation Effects Research Foundation, Hiroshima, 1988).

  14. Petridou, E. et al. Br. J. Cancer (in the press).

  15. Rothman, K. J. & Boice, J. D. Jr Publication 79–1649 (National Institutes of Health, 1979).

  16. Ross, J. A., Davies, S. M., Potter, J. D. & Robison, L. L. Epidemiol. Rev. 16, 243–271 (1994).

    Article  CAS  Google Scholar 

  17. Clearly, M. L. New Engl. J. Med. 329, 958–960 (1993).

    Article  Google Scholar 

  18. Canaani, E., Nowell, P. C. & Croce, C. M. Adv. Cancer Res. 66, 213–234 (1995).

    Article  CAS  Google Scholar 

  19. Pui, C.-H., Kane, J. R. & Crist, W. M. Leukemia 9, 762–769 (1995).

    CAS  PubMed  Google Scholar 

  20. Ford, A. M. et al. Nature 363, 358–360 (1993).

    Article  ADS  CAS  Google Scholar 

  21. Monson, R. R. & MacMahon, B. in Radiation Carcinogenesis: Epidemiology and Biological Significance (eds Boice, J. D. & Fraumeni, J. F. Jr) 97–105 (Raven, New York, 1984).

    Google Scholar 

  22. MacMahon, B. & Levy, M. A. New Engl. J. Med. 270, 1082–1085 (1964).

    Article  CAS  Google Scholar 

  23. Ericson, A. & Kallen, B. Envir. Res. 67, 149–159 (1994).

    Article  CAS  Google Scholar 

  24. Bithell, J. F. & Stewart, A. M. Brit. J. Cancer 31, 271–287 (1975).

    Article  CAS  Google Scholar 

  25. Mole, R. H. Brit. J. Cancer 62, 152–168 (1990).

    Article  CAS  Google Scholar 

  26. Gardner, M. J. et al. Br. med. J. 300, 423–429 (1990).

    Article  CAS  Google Scholar 

  27. MacMahon, B. Cancer Causes Contr. 3, 283–288 (1992).

    Article  CAS  Google Scholar 

  28. Doll, R., Evens, H. J. & Darby, S. C. Nature 367, 678–680 (1994).

    Article  ADS  CAS  Google Scholar 

Download references

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Petridou, E., Trichopoulos, D., Dessypris, N. et al. Infant leukaemia after in utero exposure to radiation from Chernobyl. Nature 382, 352–353 (1996). https://doi.org/10.1038/382352a0

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