Abstract
Objectives: To examine the associations of physical activity and body size with risk of prostate cancer.
Methods: At baseline in 1988, 8922 men (mean age 67 years) completed a health questionnaire which included information on physical activity, body weight, and waist girth. In a subgroup (74% of men), physical activity data also had been provided in 1962 or 1966 and again in 1977. Additionally, body weight measured at age 18 was available for 92% of men. During follow-up from 1988 through 1993, 439 men developed prostate cancer.
Results: In multivariate analyses that accounted for potential confounders, the RRs (95% CI) for <4200, 4200–8399, 8400–12,599, and ≥12,600 kJ/week of physical activity at baseline were 1.00 (referent), 1.13 (0.84–1.52), 0.96 (0.68–1.35), and 1.04 (0.79–1.38), respectively. For body mass indexes (BMI) of <22.5, 22.5–24.9, 25.0–27.4, and ≥27.5 kg/m2 at baseline, corresponding results were 1.00 (referent), 1.27 (0.94–1.71), 1.26 (0.92–1.72), and 1.02 (0.68–1.53), respectively. For waist girths of ≤86.4, 86.5–91.4, 91.5–96.5, and >96.5 cm, they were 1.00 (referent), 1.30 (0.96–1.76), 1.31 (0.96–1.80), and 1.19 (0.85–1.65), respectively. Combining physical activity measures from the past, or examining vigorous activities only, did not yield any significant associations. BMI at age 18 also was not related to risk.
Conclusion: These findings do not support a role of physical activity or body weight in prostate cancer etiology.
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Greenlee RT, Murray T, Bolden S, Wingo P (2000) Cancer statistics. Cancer J Clin 50: 7-33.
Wilding G (1995) Endocrine control of prostate cancer. Cancer Surv 23: 43-62.
Hovenanian MS, Denning CL (1948) The heterologous growth of cancer of the human prostate. Surg Gynecol Obstet 86: 29-35.
Gann PH, Hennekens CH, Ma J, Longcope C, Stampfer MJ (1996) Prospective study of sex hormone levels and risk of prostate cancer. J Natl Cancer Inst 88: 1118-1126.
Wheeler GD, Wall SR, Belcastro AN, et al. (1984) Reduced serum testosterone and prolactin levels in male distance runners. JAMA 254: 514-516.
Hackney C, Sinning WE, Bruot BDC (1990) Hypothalamic-pituitary-testicular axis function in endurance-trained males. Int J Sports Med 11: 298-303.
Tymchuk CN, Tessler SB, Aronson WJ, Barnard RJ (1998) Effects of diet and exercise on insulin, sex-hormone-binding globulin, and prostate-specific antigen. Nutr Cancer 31: 127-131.
Carey DG (1998) Abdominal obesity. Curr Opin Lipidol 9: 35-40.
Lee I-M, Paffenbarger RS Jr, Hsieh C-c (1992) Physical activity and risk of prostatic cancer among college alumni. Am J Epidemiol 135: 169-179.
Lee I-M, Paffenbarger RS Jr, Hsieh C-c (1992) Time-trends in physical activity among college alumni, 1962-1988. Am J Epidemiol 135: 915-925.
Albanes D, Conway JM, Taylor PR, Moe PW, Judd J (1990) Validation and comparison of eight physical activity questionnaires. Epidemiology 1: 65-71.
Washburn RA, Smith KW, Gold-eld SRW, McKinlay JB (1991) Reliability and physiologic correlates of the Harvard Alumni Activity Survey in a general population. J Clin Epidemiol 44: 1319-1326.
Ainsworth BE, Leon AS, Richardson MT, Jacobs DR, Paffenbarger RS, Jr (1993) Accuracy of the College Alumnus physical activity questionnaire. J Clin Epidemiol 46: 1403-1411.
Ainsworth BE, Haskell WL, Leon AS, et al. (1993) Compendium of physical activities: Classiffcation of energy costs of human physical activities. Med Sci Sports Exerc 25: 71-80.
Taylor HL, Jacobs DR Jr, Schucker B, Knudsen J, Leon AS, Debacker G (1978) A questionnaire for the assessment of leisure time physical activities. J Chron Dis 31: 741-755.
Pate RR, Pratt M, Blair SN, et al. (1995). Physical activity and public health: a recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. JAMA 273: 402-407.
US Department of Health and Human Services (1996) Physical Activity and Health: A Report of the Surgeon General. Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, pp 3-8; 85-172.
Lee I-M, Paffenbarger RS Jr (1998) Physical activity and stroke incidence: the Harvard Alumni Health Study. Stroke 29: 2049-2054.
Lee I-M, Pa-enbarger RS Jr (2000) The associations of light, moderate, and vigorous intensity physical activity with mortality: the Harvard Alumni Health Study. Am J Epidemiol 151: 293-299.
Cox DR (1972) Regression models and life tables. J Roy Stat Soc (B) 34: 187-220.
World Health Organization (1995) Physical Status: The use and interpretation of anthropometry. Geneva: WHO.
Hsing AW, McLaughlin JK, Zheng W, Gao Y-T, Blot WJ (1994) Occupation, physical activity, and risk of prostate cancer in Shanghai, People's Republic of China. Cancer Causes Control 5: 136-140.
Andersson S-O, Baron J, Wolk A, Lindgren C, Bergstrom R, Adami H-O (1995) Early life risk factors for prostate cancer: a population-based case-control study in Sweden. Cancer Epidemiol Biomarkers Prev 4: 187-192.
Whittemore AS, Kolonel LN, Wu AH, et al. (1995) Prostate cancer in relation to diet, physical activity, and body size in blacks, whites, and Asians in the United States and Canada. J Natl Cancer Inst 87: 652-661.
Cerhan JR, Torner JC, Lynch CF, et al. (1997) Association of smoking, body mass, and physical activity with risk of prostate cancer in the Iowa 65+ Rural Health Study (United States). Cancer Causes Control 8: 229-238.
Hartman TJ, Albanes D, Tautalahti M, et al. (1998) Physical activity and prostate cancer in the Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention Study (Finland). Cancer Causes Control 9: 11-18.
Giovannucci E, Leitzmann M, Spiegelman D, et al. (1998) A prospective study of physical activity and prostate cancer in male health professionals. Cancer Res 58: 5117-5122.
Sung JFC, Kin RS, Pu Y-S, Chen Y-C, Chang HC, Lai M-K (1999) Risk factors for prostate carcinoma in Taiwan: a case-control study in a Chinese population. Cancer 86: 484-491.
Villeneuve PJ, Johnson KC, Krieger N, Mao Y, and the Canadian Cancer Registries Epidemiology Research Group (1999) Risk factors for prostate cancer: results from the Canadian National Enhanced Cancer Surveillance System. Cancer Causes Control 10: 355-367.
Liu S, Lee I-M, Linson P, Ajani U, Buring JE, Hennekens CH (2000) A prospective study of physical activity and risk of prostate cancer in US physicians. Int J Epidemiol 29: 29-35.
Polednak AP (1976) College athletics, body size, and cancer mortality. Cancer 38: 382-387.
Le Marchand L, Kolonel LN, Yoshizawa CN (1991) Lifetime occupational physical activity and prostate cancer risk. Am J Epidemiol 133: 103-111.
Calle E (2000) Do anthropometric measures predict risk of prostate cancer? Am J Epidemiol 151: 550-553.
Andersson SO, Wolk A, Bergstrom R, et al. (1995) Body size and prostate cancer: a 20-year follow-up study among 135 006 Swedish construction workers. J Natl Cancer Inst 89: 385-389.
Giovannucci E, Rimm EB, Stampfer MJ, Colditz GA, Willett WC (1997) Height, body weight, and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 6: 557-563.
Nilsen TIL, Latten LJ (1999) Anthropometry and prostate cancer risk: a prospective study of 22,248 Norwegian men. Cancer Causes Control 10: 269-275.
Schuurman AG, Goldbohm RA, Dorant E, van den Brandt PA (2000) Anthropometry in relation to prostate cancer risk in the Netherlands Cohort Study. Am J Epidemiol 151: 541-549.
Mantzoros CS, Tzonou A, Signorello LB, Stampfer MJ, Trichopoulos DS, Adami HO (1997) Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia. Br J Cancer 76: 1115-1118.
Chan JM, Stampfer MJ, Giovannucci E, et al. (1998) Plasma insulin-like growth factor-1 and prostate cancer risk: a prospective study. Science 279: 563-566.
Scacchi M, Pincelli AI, Cavagnini F (1999) Growth hormone in obesity. Int J Obes 23: 260-271.
Nam SY, Lee EJ, Kim KR, et al. (1997) Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (BP)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone. Int J Obes 21: 355-359.
Vermeulen A, Kaufman JM, Giagulli VA (1996) Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males. J Clin Endocrinol Metab 81: 1821-1826.
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Lee, IM., Sesso, H.D. & Paffenbarger, R.S. A prospective cohort study of physical activity and body size in relation to prostate cancer risk (United States). Cancer Causes Control 12, 187–193 (2001). https://doi.org/10.1023/A:1008952528771
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DOI: https://doi.org/10.1023/A:1008952528771