Abstract
Objectives: The objective of this study was to assess the risk of incidental prostate cancer associated with occupational physical activity in a population of patients treated for benign prostatic hyperplasia (BPH) by transurethral resection of the prostate (TURP).
Methods: This case–control study was conducted in men aged 45 and over referred for TURP to relieve the symptoms of BPH in one of the eight hospitals of the Quebec City area between October 1990 and December 1992. Cases (n = 64) were all men incidentally diagnosed with prostate cancer and controls were the 546 patients with solely a histological diagnosis of BPH. At the time of their interview, the patients completed a diet history questionnaire and a general questionnaire including a lifetime occupational history. Physical activity was estimated for each job according to data from the US Department of Labor. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI) of incidental prostate cancer associated with occupational physical activity while adjusting for confounders.
Results: A positive association was observed between “ever having a job with sedentary/light work” and incidental prostate cancer (OR = 1.9; 95% CI = 1.1–3.3). ORs for prostate cancer associated with 0%, 1–49%, and ≥50% of life spent in jobs with sedentary/light work were 1.0, 1.6 (95% CI = 0.8–3.1), and 2.5 (95% CI = 1.2–5.2), respectively (p-value for trend = 0.01). Occupational physical activity in the job held during the longest period was inversely associated with prostate cancer: ORs were 1.0, 0.5 (95% CI = 0.2–1.2), 0.4 (95% CI = 0.2–0.9) and 0.2 (95% CI = 0.1–0.7) for sedentary, light, moderate, and high/very high levels, respectively (p-value for trend = 0.008).
Conclusions: The results of this study suggest that physical activity at work could have a beneficial effect on the occurrence of prostate cancer.
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References
Oliveria SA, Lee IM (1997) Is exercise beneficial in the prevention of prostate cancer. Sports Med 23: 271–278.
Hackney AC (1989) Endurance training and testosterone levels. Sports Med 8: 117–127.
Bolla M, Gonsalez D, Warde P, et al. (1997) Improved survival in patients with locally advanced prostate cancer treated with radiotherapy and goserelin. N Engl J Med 337: 295–300.
Chan JM, Stampfer MJ, Giovannucci E, et al. (1998) Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science 279: 563–566.
Wolk A, Mantzoros CS, Andersson SO, et al. (1998) Insulin-like growth factor 1 and prostate cancer risk: a population-based, case-control study. J Natl Cancer Inst 90: 911–915.
Eliakim A, Brasel JA, Mohan S, Wong WLT, Cooper DM (1998) Increased physical activity and the growth hormone-IGF-I axis in adolescent males. Am J Physiol 275: 308–314.
Rudman D, Mattson DE (1994) Serum insulin-like growth factor I in healthy older men in relation to physical activity. J Am Geriatr Soc 42: 71–76.
Shephard RJ, Shek PN (1998) Associations between physical activity and susceptibility to cancer: possible mechanisms. Sports Med 26: 293–315.
Meyer F, Bairati I, Fradet Y, Moore L (1997) Dietary energy and nutrients in relation to preclinical prostate cancer. Nutr Cancer 29: 120–126.
Vena JE, Graham S, Zielezny M, Brasure J, Swanson MK (1987) Occupational exercise and risk of cancer. Am J Clin Nutr 45: 318–327.
Le Marchand L, Kolonel LN, Yoshizawa CN (1991) Lifetime occupational physical activity and prostate cancer risk. Am J Epidemiol 133: 103–111.
US Department of Labor (1966) Selected characteristics of occupations (physical demands, working conditions, training time), a supplement to the Dictionary of Occupational Titles (1966). Washington, DC: US GPO, 3rd edn.
Ainsworth B, Haskell W, Leon A, et al. (1993) Compendium of physical activities: classification of energy costs of human physical activities. Med Sci Sports Exerc 25: 71–80.
Albanes D, Blair A, Taylor PR (1989) Physical activity and risk of cancer in the NHANES I population. Am J Public Health 79: 744–750.
Brownson RC, Chang JC, Davis JR, Smith CA (1991) Physical activity on job and cancer in Missouri. Am J Public Health 81: 639–642.
Hartman TJ, Albanes D, Rautalahti M, et al. (1998) Physical activity and prostate cancer in the Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention Study. Cancer Causes Control 9: 11–18.
Hsing AN, McLaughlin JK, Zheng W, Gao YT, Blot WJ (1994) Occupation, physical activity, and risk of prostate cancer in Shanghai, People's Republic of China. Cancer Causes Control 5: 136–140.
Dosemeci M, Hayes RB, Vetter R, et al. (1993) Occupational physical activity, socioeconomic status, and risks of 15 cancer sites in Turkey. Cancer Causes Control 4: 313–321.
Thune I, Lund E (1994) Physical activity and risk of prostate and testicular cancer: a cohort study of 53,000 Norwegian men. Cancer Causes Control 5: 549–556.
Paffenbarger RS, Hyde RT, Wing AL (1987) Physical activity and incidence of cancer in diverse populations: a preliminary report. Am J Clin Nutr 45: 312–317.
Severson RK, Nomura AMY, Grove JS, Stemmermann GN (1989) A prospective analysis of physical activity and cancer. Am J Epidemiol 130: 522–529.
Whittemore AS, Kolonel LN, Wu AH, et al. (1995) Prostate cancer in relation to diet, physical activity, and body size in blacks, whites, and asians in the United States and Canada. J Natl Cancer Inst 87: 652–661.
Ross RK, Schottenfeld D (1996) Prostate cancer. In: Schottenfeld D, Fraumeni JF, (eds.) Cancer Epidemiology and Prevention, 2nd edn. New York: Oxford University Press, pp 1180–1206.
Colditz GA, Cannuscio CC, Frazier AL (1997) Physical activity and reduced risk of colon cancer: implications for prevention. Cancer Causes Control 8: 649–667.
Wu AH, Whittemore AS, Kolonel LN, et al. (1995) Serum androgens and sex hormone-binding globulins in relation to lifestyle factors in older African-American, white, and Asian men in the United Sates and Canada. Cancer Epidemiol Biomarkers Prev 4: 735–741.
Dunn SE, Kari FW, French J, et al. (1997) Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice. Cancer Res 57: 4667–4672.
Hursting SD, Switzer BR, French JE, Kari FW (1993) The growth hormone: insulin-like growth factor 1 axis is a mediator of diet restriction-induced inhibition of mononuclear cell leukemia in Fisher rats. Cancer Res 15: 2750–2757.
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Bairati, I., Larouche, R., Meyer, F. et al. Lifetime occupational physical activity and incidental prostate cancer (Canada). Cancer Causes Control 11, 759–764 (2000). https://doi.org/10.1023/A:1008936826337
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DOI: https://doi.org/10.1023/A:1008936826337