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Modification of cancer risk in offspring by parental cancer (Sweden)

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Abstract

Objectives: Familial cancer risks were studied in offspring whose parents had a similar (concordant) or a different (discordant) cancer in order to assess the modification of cancer risks from one generation to another.

Methods: We used the nation-wide Swedish Family-Cancer Database to calculate familial rate ratios (FRRs) to the offspring when their parents had concordant and discordant cancers. Cancer sites were included if there was at least one pair of parents with the same cancer. In situ cancers were included in a separate analysis in order to increase the numbers of cases.

Results: The risk of colon, all bowel, lung and breast cancer and melanoma increased 1.1–1.2 times when one parent and 1.3–1.6 times when two parents had any discordant cancer, suggesting involvement of environmental and hereditary effects shared by many forms of cancer. When both parents had colon cancer or melanoma, the respective risks in the offspring were 3.0 and 9.3 but only based on single triplets. For all bowel cancer the risk was 3.4, approximately multiplicative from the familial one parent-offspring risk. For concordant lung and breast cancer triplets the risk in offspring was 11.8 and 29.4, respectively.

Conclusions: Even discordant cancer in parents increased cancer risk in offspring. This may be due to environmental and hereditary causes, and deserves consideration in epidemiological studies. The high risks in families where both parents had the same cancer suggest interactions of hereditary and environmental factors.

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References

  1. Knudson Jr AG (1985) Hereditary cancer, oncogenes, and antioncogenes. Cancer Res 45: 1437-1443.

    Google Scholar 

  2. Li FP (1995) Phenotypes, genotypes, and interventions for hereditary cancers. Cancer Epidemiol Biomarkers Prev 4: 579-582.

    Google Scholar 

  3. Goldgar DE, Easton DF, Cannon-Albright LA, Skolnick MH (1994) Systematic opulation based assessment of cancer risk in first degree relatives of cancer probands. J Natl Cancer Inst 86: 1600-1607.

    Google Scholar 

  4. Carstensen B, Soll-Johanning H, Villadsen E, Södergaard JO, Lynge E (1996) Familial aggregation of colorectal cancer in the general population. Int J Cancer 68: 428-435.

    Google Scholar 

  5. Easton DF, Matthews FE, Ford D, Swerdlow AJ, Peto J (1996) Cancer mortality in relatives of women with ovarian cancer: the OPCS study. Int J Cancer 65: 284-294.

    Google Scholar 

  6. Peto J, Easton DF, Matthews FE, Ford D, Swerdlow AJ (1996) Cancer mortality in relatives of women with breast cancer: the OPCS study. Int J Cancer 65: 275-283.

    Google Scholar 

  7. Hemminki K, Vaittinen P (1997) Familial cancer in Sweden: population-based study. Int J Oncol 11: 273-280.

    Google Scholar 

  8. Hemminki K, Vaittinen P (1997) Effect of paternal and maternal cancer on cancer in the offspring: population-based study. Cancer Epidemiol Biomarkers Prev 6: 993-997.

    Google Scholar 

  9. Hemminki K, Vaittinen P (1998) National database of familial cancer in Sweden. Genet Epidemiol 15: 225-236.

    Google Scholar 

  10. Hemminki K, Vaittinen P, Kyyrönen P (1998) Age-specific familial risks in common cancer of the offspring. Int J Cancer 78: 172-175.

    Google Scholar 

  11. Boyd M, Harris F, McFarlane R, Davidson RH, Black D (1995) A human BRCA1 gene knockout. Nature 375: 541-542.

    Google Scholar 

  12. Hackman P, Tannergård P, Osei-Mensa S, Chen J, Kane MF, Kolodner R, Lambert B, Hellgren D, Lindblom A (1997) A human compound heterozygote for two MLH1 misssense mutations. Nature Genet 17: 135-136.

    Google Scholar 

  13. Brugarolas J, Jacks T (1997) Double indemnity: p53, BRCA and cancer. Nature Medicine 7: 721-722.

    Google Scholar 

  14. Hemminki K, Vaittinen P (1997) Interaction of breast cancer and melanoma genotypes. Lancet 350: 931-932.

    Google Scholar 

  15. Hemminki K, Vaittinen P (1998) Familial breast cancer in the Family-Cancer Database. Int J Cancer 77: 386-391.

    Google Scholar 

  16. Centre for Epidemiology, Cancer Incidence in Sweden (1995) The National Board of Health and Welfare, Stockholm.

    Google Scholar 

  17. Hemminki K, Vaittinen P (1998) Familial etiology in in situ cancers analysed from the Family-Cancer Database. Cancer Epidemiol Biomarkers Prev 7: 865-868.

    Google Scholar 

  18. Cancer: Causes, Occurrence and Control (1990) L. Tomatis (ed.), IARC Scientific Publication no. 100, IARC, Lyon.

    Google Scholar 

  19. Michels KB, Trichopoulos D, Robins JM, Rosner BA, Manson JE, Hunter DJ, Colditz GA, Hankinson SE, Speizer FE, Willet WC (1996) Birthweight as a risk factor for breast cancer. Lancet 348: 1542-1546.

    Google Scholar 

  20. Garland M, Hunter DJ, Colditz GA, Manson JE, Stampfer MJ, Spiegelman D, Speizer F, Willett WC (1998) Menstrual cycle characteristics and history of ovulatory infertility in relation to breast cancer risk in a large cohort of US women. Am J Epidemiol 147: 636-643.

    Google Scholar 

  21. Coldiz GA (1998) Relationship between estrogen levels, use of hormone replacement therapy, and breast cancer. J Natl Cancer Inst 90: 814-823.

    Google Scholar 

  22. Huang Z, Hankinson SE, Colditz GA, Stampfer MJ, Hunter DJ, Manson JE, Hennekiens CH, Rossner B, Speizer FE, Willett WC (1997) Dual effects of weight and weight gain on breast cancer risk. JAMA 278: 1407-1411.

    Google Scholar 

  23. Håkansson S, Johannsson O, Johansson U, Sellberg G, Loman N, Gerdes A-M, et al. (1997) Moderate frequencies of BRCA1 and BRCA2 germ-line mutations in Scandinavian familial breast cancer. Am J Hum Genet 60: 1060-1078.

    Google Scholar 

  24. Zelada-Hedman M, Wasteson Arver B, Claro A, Werelius B, Kok H, Sanselin K, et al. (1997) A screening for BRCA1 mutations in breast and breast-ovarian cancer families from the Stockholm region. Cancer Res 57: 2474-2477.

    Google Scholar 

  25. Ford D, Easton DF, Peto J (1995) Estimates of gene frequency of BRCA1 and its contribution to breast and ovarian cancer incidence. Am J Hum Genet 57: 1457-1462.

    Google Scholar 

  26. Friedman LS, Gayther SA, Kurosaki T, Gordon D, Noble B, Casey G, et al. (1997) Mutation analysis of BRCA1 and BRCA2 in male breast cancer population. Am J Hum Genet 60: 313-319.

    Google Scholar 

  27. Claus E, Schildkraut JM, Thompson WD, Risch NJ (1996) The genetic attributable risk of breast and ovarian cancer. Cancer 77: 2318-2324.

    Google Scholar 

  28. Pharoah PDP, Day NE, Duffy S, Easton DF, Ponder BAJ (1997) Family history and the risk of breast cancer: a systematic review and meta-analysis. Int J Cancer 71: 800-809.

    Google Scholar 

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Authors and Affiliations

  1. Department of Biosciences at Novum, Karolinska Institute, CNT Novum, 141 57, Huddinge, Sweden

    Kari Hemminki, Pauli Vaittinen & Pentti Kyyrönen

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  1. Kari Hemminki
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  2. Pauli Vaittinen
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  3. Pentti Kyyrönen
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Hemminki, K., Vaittinen, P. & Kyyrönen, P. Modification of cancer risk in offspring by parental cancer (Sweden). Cancer Causes Control 10, 125–129 (1999). https://doi.org/10.1023/A:1008896712363

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