EditorialHave we been wrong about ionizing radiation and chronic lymphocytic leukemia?
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Acknowledgement
There is no one to acknowledge. I have no interests to declare. This is all my own work.
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Cited by (18)
Radiation and leukaemia: Which leukaemias and what doses?
2023, Blood ReviewsCitation Excerpt :However, 2 studies of incidence data reported no increase in CLL [92]. Taken together these data suggest a possible need to revise our notion CLL is not a radiogenic leukaemia [91,93,94,95]. Discussed above is the dramatic increase in AML risk in persons receiving radiation therapy for cancers such as Hodgkin lymphoma and benign disorders such as ankylosing spondylitis.
The mystery of chronic lymphocytic leukemia (CLL): Why is it absent in Asians and what does this tell us about etiology, pathogenesis and biology?
2015, Blood ReviewsCitation Excerpt :These data suggest there may be some environmental impact on CLL incidence. Several other risk factors for CLL in persons of predominately European descent are reported including tobacco use (see below), some chemicals, herbicides (such as found in Agent Orange), benzene and other aromatic hydrocarbons, and ionizing radiations [114–121]. Because CLL likely has a long latency, the appropriate time to compare exposure to these agents is several decades ago for the current older Asian population.
Chronic lymphocytic leukaemia
2008, The LancetCitation Excerpt :On Jan 23, 2003, the US National Academy of Sciences' Institute of Medicine published a report concluding that there is “sufficient evidence of an association between exposure to Agent Orange, a herbicide used in Viet Nam, and the development of chronic lymphocytic leukaemia”.11 Although ionising radiation has traditionally been absolved from causing chronic lymphocytic leukaemia, recent studies have suggested that this may be unwarranted.12 Clinical diagnosis of chronic lymphocytic leukaemia is defined by absolute lymphocytosis of at least 5×109/L mature-appearing lymphocytes and an appropriate immunophenotype (figure).13
Epidemiology and etiology of leukemia and lymphoma
2020, Cold Spring Harbor Perspectives in Medicine