Mechanisms of asthma and allergic inflammationGenome screen for asthma and bronchial hyperresponsiveness: Interactions with passive smoke exposure
Section snippets
Family ascertainment
Two hundred families were ascertained through probands who were initially studied between 1962 and 1975 at Beatrixoord Hospital, Haren, the Netherlands, a regional airways disease referral center. Patients with newly diagnosed symptomatic asthma who were not experiencing a current asthma exacerbation were referred to this hospital and admitted for a standardized and comprehensive evaluation for asthma and atopy. At the time of initial testing, all probands had asthma symptoms, were
Demographics
The characteristics of the family members have been described previously.10 Fig 1 shows the results of the asthma classification of the first- and second-degree offspring (n = 540) for the 200 families. Class 1 (definite asthma) was found in 21% of the offspring, whereas class 2 (probable asthma) was found in 10%, resulting in 31% of the offspring with findings consistent with a diagnosis of asthma, even though these 200 families were not ascertained for multiple family members with asthma. Class
Discussion
This study reports the results of linkage analysis for asthma and bronchial responsiveness by using a well-characterized, homogeneous asthmatic family population. The families were not ascertained through multiple affected siblings but through a single proband (a parent) with asthma, and analysis of the offspring showed a high frequency of asthma phenotypes (31% with asthma or probable asthma [classes 1 and 2] and 46% with BHR), supporting an important hereditary component for these phenotypes.
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Supported by the Dutch Asthma Funds grant AF 95.09 and National Institutes of Health (NIH) grants R01HL/48341 and R01HL/66393.