ORIGINAL ARTICLESGenetic polymorphisms as biomarkers of sensitivity to inhaled sulfur dioxide in subjects with asthma
REFERENCES (29)
- et al.
Association of Glu 27 β2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects
Lancet
(1995) - et al.
The effects of sulfur oxides on nasal and lung function in adolescents with extrinsic asthma
J Allergy Clin Immunol
(1985) - et al.
The–308 TNF-α promoter polymorphism effects transcription
Mol Immunol
(1997) - et al.
Overview
Genetics and pulmonary medicine: asthma
Thorax
(1999)Polymorphisms of the β2-adrenergic receptor and asthma
Am J Respir Crit Care Med
(1997)- et al.
Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties
Biochemistry
(1994) - et al.
Genetic polymorphisms of the β2-adrenergic receptor in nocturnal and nonnocturnal asthma: evidence that Gly16 correlates with the nocturnal phenotype
J Clin Invest
(1995) - et al.
The association of atopy with a gain-of-function mutation in the a subunit of the interleukin-4 receptor
N Engl J Med
(1997) - et al.
A polymorphism of the CC16 gene is associated with an increased risk of asthma
J Med Genet
(1998)
Tumor necrosis factor-α increases airway responsiveness and sputum neutrophilia in normal human subjects
Am J Respir Crit Care Med
Tumour necrosis factor haplotypes and asthma
Hum Mol Genet
Prevalence of tumor necrosis factor-α and angiotensin converting enzyme polymorphisms in mild/moderate and fatal/near-fatal asthma
Am J Respir Crit Care Med
Association within the tumor necrosis factor (TNF) genes and childhood asthma
Clin Exp Allergy
Cited by (33)
Short-term associations of ambient air pollution and cause-specific emergency department visits in Guangzhou, China
2018, Science of the Total EnvironmentCitation Excerpt :In the present study, a 7.98 μg/m3 increase in SO2 was associated with a 5.19% increase in circulatory emergency visits for the 2-day moving average exposure, and the association for circulatory visits was somewhat stronger than that (4.89%) for neurologic visits. Inhalation of SO2 leads to rapid-onset bronchoconstriction, and the pulmonary function in asthmatic patients was damaged obviously, potentially resulting from a TNF-α promoter polymorphism identified in the patients (Horstman, 1989; Winterton et al., 2001). In our study, associations were often of stronger magnitude in the cold season (November–April) compared with the warm season (May–October) for SO2 in season-specific analyses (Table 2).
Ambient air pollution
2016, Journal of Allergy and Clinical ImmunologyA review on human health perspective of air pollution with respect to allergies and asthma
2013, Environment InternationalCitation Excerpt :In response to the inhalation of SO2 (e.g., 0.25 ppm), asthmatic subjects experienced pronounced symptoms of reduced pulmonary function relative to nonasthmatic subjects who were often unresponsive at less than 5 ppm (Meng et al., 2003). In another study, the TNF-α promoter polymorphism was identified in asthmatic patients who were exposed to 0.5 ppm of SO2 for 10 minutes (Winterton et al., 2001). As ambient SO2 can contribute to the formation of acid aerosol (H2SO4), some studies suggested the possibility of increasing asthma symptoms on days with highly acidic aerosols (U.S. Environmental Protection Agency, U.S. EPA, 2008).
Impact of pollution on asthma in young infants
2011, Revue Francaise d'AllergologieSensory and pulmonary effects of acute exposure to sulfur dioxide (SO<inf>2</inf>)
2010, Toxicology LettersOxidants and the pathogenesis of lung diseases
2008, Journal of Allergy and Clinical ImmunologyCitation Excerpt :Yang et al173 found that among 51 adult subjects exposed to O3 during intermittent exercise, those with the TNF -308 G/G genotype (wild-type) had a significantly greater fall in FEV1 (–9% of baseline) compared with subjects with a loss-of-function -308 A allele (G/A or A/A genotype). Interestingly, a similar association of TNF genotypes was found in adult subjects with asthma exposed to 0.5 ppm SO O3 during moderate exercise.174 The role of TNF was also investigated by Li et al,175 who found that children with -308 G/G TNF genotype had decreased risk of asthma and lifetime wheezing compared with children who had 1 or more of the mutant alleles.
This research was supported in part by University of Washington Center Grant P30 ES07033.