Multiple sclerosis: an immune legacy?
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Is environmental radon gas associated with the incidence of neurodegenerative conditions? A retrospective study of multiple sclerosis in radon affected areas in England and Wales
2016, Journal of Environmental RadioactivityCitation Excerpt :Lykken and Momčilović (2003a, 2003b) proposed that myelin sheath lipids take up inhaled lipid-soluble environmental radon; in this delicate and sensitive environment, subsequent α- and β-particle bombardment irreversibly damages myelin cell nuclei, puncturing the myelin sheaths beyond the point of repair and causing permanent nerve impulse propagation failure. An additional outcome of this irradiation is free-radical generation, leading to potential peroxidative damage to the myelin lipid portion (Cooper, 1997). Together with other studies (Hursh et al., 1965; Nussbaum and Hursh, 1965), this potentially provides a mechanism for delivering a significant radiation dose to the cells involved in MS.
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