Mutation Research/Environmental Mutagenesis and Related Subjects
Biomarkers of effect in evaluating metalaxyl cocarcinogenesis selective induction of murine CYP 3A isoform
References (34)
- et al.
A pleiotropic response to phenobarbital-type enzyme inducers in the F344/NCr rat
Biochem. Pharmacol.
(1992) - et al.
On the nature of non-genotoxic carcinogens. A unified theory including NGCs, co-carcinogens and promoters
Mutation Res.
(1992) - et al.
Further mechanisms of non-genotoxic carcinogenesis
Trends Pharmacol. Sci.
(1994) - et al.
Induction of CYP2B1 mediated pentoxyresorufin O-dealkylase activity in different species sex and tissue by prototype 2B1-inducers
Chem. Biol. Interact.
(1995) - et al.
The carbon monoxide-binding pigment of liver microsomes I. Evidence for its hemo-protein nature
J. Biol. Chem.
(1964) - et al.
Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome(s) P450 by phenobarbital and other xenobiotics in rat
Arch. Biochem. Biophys.
(1985) - et al.
Ethoxy-, pentoxy- and benzyloxy-phenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P450
Biochem. Pharmacol.
(1985) A simple and sensitive assay of 7-ethoxycoumarin deethylation
Anal. Biochem.
(1978)- et al.
Protein measurement with Folin phenol reagent
J. Biol. Chem.
(1951) - et al.
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Anal. Biochem.
(1987)
Technique for identifying and minimizing solvent-pesticides interaction in bioassays
Arch. Environ. Contam. Toxicol.
Mode of action of systemyc fungicides
Prog. Pest. Biochem. Toxicol.
Mobility, distribution and persistence of metalaxyl residues in Pearl Millet (Pennisetum americanum (L.) Leeke.)
Bull. Environ. Contam. Toxicol.
Toxicological evaluation of fungicides by genotoxic activity profiles and experimental studies in DNA unwinding florimetric assay
Pharmacol. Toxicol.
Food and Agricolture organization of the United Nations. Pesticide residues in food-evaluation 1980
Multi end-point procedures to evaluate risk from pesticides
Environ. Health Persp.
In vitro transforming effect of the fungicides metalaxyl and Zineb
Teratogen. Carcinogen. Mutagen.
Cited by (20)
Acylamino acid chiral fungicides on toxiciepigenetics in lambda DNA methylation
2017, Food and Chemical ToxicologyCitation Excerpt :Although AACFs does not show evidence of carcinogenicity and teratogenicity in animals, it may have potential toxicological effects on mammals. It has been proven that metalaxyl could induce murine CYP 3A and increase the amount of CYP 3A cDNA hybridization mRNA in liver, which indicates CYP expression seems to be regulated by mRNA (Paolini et al., 1996). Hrelia et al. detected the clastogenicity of metalaxyl in vitro of human lymphocyte cultures (Hrelia et al., 1996).
Evaluating the enantioselective degradation and novel metabolites following a single oral dose of metalaxyl in mice
2014, Pesticide Biochemistry and PhysiologyCitation Excerpt :Studies have indicated that metalaxyl has cytogenetic effects on human and animal chromosomes in vitro [11] and liver is the primary target for metalaxyl-treated mice [12]. Paolini et al. reported the cocarcinogenic potential of metalaxyl in Swiss albino mice [13] and metalaxyl was found to induce nephrotoxicity in mice [14]. In our previous study [15], the enantioselective degradation of metalaxyl in rat and rabbit hepatic microsomes in vitro was investigated, finding that S-metalaxyl degraded much faster than R-metalaxyl.
Enantioselective separation and transformation of metalaxyl and its major metabolite metalaxyl acid in tomato and cucumber
2013, Food ChemistryCitation Excerpt :Moreover, metalaxyl has been found to induce skin irritation, accumulate in the liver, muscles, or fat, and cause tumours of suprarenal thyroid glands (Saab et al., 2011). Paolini et al. also suggested that a cocarcinogenic potential of metalaxyl could be sufficient to cause critical DNA damage either directly, by way of oxygen radical overgeneration, or indirectly, via increased activation of ubiquitous precarcinogens (Paolini, Mesirca, Pozzetti, Sapone, & CantelliForti, 1996). Established data show that many chiral pesticides residues occur non-racemically and can be metabolised enantioselectively (Garrison, Avants, & Jones, 2011; Jarman, Jones, Howell, & Garrison, 2005; Lewis et al., 1999; Li, Zhang, Li, Wang, & Li, 2011; Li et al., 2012).
In vitro metabolism and interactions of the fungicide metalaxyl in human liver preparations
2007, Environmental Toxicology and PharmacologyCitation Excerpt :An extensive in vitro screening of potential CYP-based interactions indicated that metalaxyl is a relatively modest inhibitor of 7-pentoxyresorufin-O-dealkylation (CYP2B) and bupropion hydroxylation (CYP2B6) and did not have any significant inhibitory effect towards other CYPs in human liver microsomes. The only available study on potential interactions in animals was an in vivo investigation by Paolini et al. (1996), in which mice were treated intraperitoneally with either single or repeated doses of metalaxyl. There was about a threefold increase in (presumably) CYP3A isoenzymes as indicated by N-demethylation of aminopyrine and a weak but significant reduction in CYP2B1 activity in mouse liver.
Enantioselective degradation kinetics of metalaxyl in rabbits
2005, Pesticide Biochemistry and Physiology