Research LettersPesticide exposure and risk of mild cognitive dysfunction
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Cited by (69)
Pesticides, cognitive functions and dementia: A review
2020, Toxicology LettersCitation Excerpt :The observation of an exponential increase in dementia and cognitive decline prevalence with age has motivated the inclusion of older people in studies focusing on links between exposure and cognitive impairment. Within the context of the Maastricht Aging Study, Bosma et al. (2000) have examined 830 non-demented 50-to-80-year-old individuals and reported that exposed (to unspecified pesticides) individuals had a five-fold risk of mild cognitive dysfunction as compared to the non-exposed group (Bosma et al., 2000). Steenland et al. (2013) assessed 400 elderly residents of government-run clinics.
Pesticide exposure and cognitive function: Results from the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD)
2019, Environmental ResearchCitation Excerpt :In a recent systematic review, pesticide exposure was even characterized as a moderate putative risk factor of dementia (Killin et al., 2016), and an additional positive association between pesticide exposure and AD was suggested in a recent meta-analysis (Yan et al., 2016), confirming that pesticide exposure might indeed be a risk factor for AD. Pesticide exposure has also been associated with mild cognitive impairment (MCI) (Bosma et al., 2000), as well as vascular dementia (VD) and PD-dementia, but not frontotemporal lobar degeneration (FTLD) (Zaganas et al., 2013). In addition, different aspects of cognitive performance (selective attention, symbol-digit, Mini-Mental State Examination score, reaction time tests) seem to be adversely influenced by pesticide exposure (Baldi et al., 2011; Rohlman et al., 2007; Zaganas et al., 2013).
Reflections on the process of using systematic review techniques to evaluate the literature regarding the neurotoxicity of low level exposure to organophosphate pesticides
2016, Environment InternationalCitation Excerpt :Others studies used proxy measures of exposure such as occupational group or area of residency so causality and dose–response relationships could not be determined (Beseler et al., 2006; Browne et al., 2006; Cole et al., 1997; Kamel et al., 2003; Parron et al., 1996; Rohlman et al., 2007). Seven studies failed to provide detailed information about exposure history (Bosma et al., 2000; Dimich-Ward et al., 1996; Kilburn, 1999; Korsak and Sato, 1977; Kurlychek & Morrow, 1989; Richter et al., 1992; Starks et al., 2012); and eight used subjective symptom questionnaires (Ahmed and Davies, 1997; Ciesielski et al., 1994; Cox et al., 2005; Davies et al., 1999; Kamel et al., 2007; Ohayo-Mitoko et al., 2000; Smit et al., 2003; Solomon et al., 2007). Previous reviews of the literature regarding the neurotoxicity of low level exposure to OPs have included these studies without noticing or discussing the fact that they do not adequately address the issue of whether cumulative low level exposure to OPs is associated with neurobehavioural impairment (COT Report, 1999 updated in 2014).
Meta-analysis on occupational exposure to pesticides - Neurobehavioral impact and dose-response relationships
2015, Environmental Research