Original articleFrequency of trisomy 21 in Germany before and after the Chernobyl accident
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Cited by (33)
Why is oocyte aneuploidy increased with maternal aging?
2020, Journal of Genetics and GenomicsCitation Excerpt :When DS was first described by Langdon Down, he believed that parental tuberculosis was the cause for babies with DS although no evidence by now supports his point (Down, 1995). After the finding of trisomy 21 in patients with DS in 1959 (Jacobs et al., 1959; Lejeune and Turpin, 1962), investigators have found that some other factors but not tuberculosis have a weak or strong correlation with DS, such as seasonality of pregnancy (Jongbloet et al., 1982; Kallen and Masback, 1988), ionizing radiation (Sperling et al., 1991, 2012), homocysteine metabolism (James et al., 1999) and obesity (Hildebrand et al., 2014). If and how seasonality takes effects on oocytes is not well known; however, as both HFD (Luzzo et al., 2012; Yun et al., 2019) and maternal diabetes (Wang et al., 2009) could increase the aneuploidy rate in oocytes, seasonally-specific fat or sugar diet might be the reason why seasonality showed weak correlations with oocyte aneuploidization, but this needs further clarification.
Low dose or low dose rate ionizing radiation-induced health effect in the human
2018, Journal of Environmental RadioactivityCitation Excerpt :Mental health and psychological effects are crucial social and medical problem for society at exposure to LDIR, especially following Chornobyl (1986) and Fukushima (2011) nuclear accidents. The increased prevalence of Down's syndrome cases in West Berlin (Sperling et al., 1991, 1994) and in Republic of Belarus (Zatsepin et al., 2004) has also been reported to be causally related to a short period of exposure to ionizing radiation as a result of the Chornobyl reactor accident. Elevated mental disorders (Nyagu et al., 1998), neural tube defects, conjoined twins and teratomas, microcephaly and microphthalmia (Wertelecki, 2010) were also reported in prenatally irradiated children after Chornobyl disaster.
Prenatal irradiation–induced brain neuropathology and cognitive impairment
2017, Brain and DevelopmentCitation Excerpt :Epidemiological studies of A-bomb survivors with abnormal neuronal migration and small head size indicate that 83% of them are prenatally exposed to radiation >0.1 Gy at 8–15 weeks [20,24–28]. While it may still be debated, Down’s syndrome and related abnormalities have been reported in those prenatally exposed to higher background radiation in the coastal Kerala population in India [29,30] and to fallout of Chernobyl reactor accident [31–33]. In the latter, neural tube defects and microcephaly are also observed after prenatal radiation exposure [34].
Modeling human genetic radiation risks around nuclear facilities in Germany and five neighboring countries: A sex ratio study
2016, Environmental Modelling and SoftwareDown syndrome time-clustering in January 1987 in Belarus: Link with the Chernobyl accident?
2007, Reproductive ToxicologyAneuploidy: A report of an ECETOC task force
1998, Mutation Research - Reviews in Mutation Research