Contributed paperChanges in lymphocyte single strand breakage and liver function of workers exposed to vinyl chloride monomer
References (32)
- et al.
Sister chromatid exchanges, proliferating index, and micronuclei in biomonitoring of internal exposure to vinyl chloride monomer in plastic industry workers
Toxicol. Appl. Pharmacol.
(1991) - et al.
Single-strand breaks in DNA during repair of UV-induced damage in normal human and Xerodenna Pigmentosum cells as determined by alkaline DNA unwinding and hydroxy-lapatite chromatography
Mutat. Res.
(1979) - et al.
Induction and disappearance of DNA single-strand breaks in human B and T lymphocytes after exposure to ethylnitrosourea
Mutat. Res, DNA Repair
(1991) Gamma-glutamyl transpeptidase
Adv. Clin. Chem.
(1975)- et al.
Occupational acroosteolysis. A report of 31 cases
J. Am. Med. Assoc.
(1967) - et al.
Acro-osteolysis occurring in men engaged in the polymerization of vinyl chloride
Br. Med. J.
(1967) - et al.
On the so called Vinyl Chloride disease
Dutsch. Med. Weschr.
(1973) - et al.
Occupational acroosteolysis. I. An epidemiological study
Arch. Environ. Health
(1971) - et al.
Occupational acroosteolysis. II. An industrial hygiene study
Arch. Environ. Health
(1971) - et al.
Occupational acroosteolysis. III. A clinical study
Arch. Environ. Health
(1971)
An industry-wide epidemiologic study of vinyl chloride workers, 1942–1982
Am. J. Ind. Med.
Cohort and case-control analyses of workers exposed to vinyl chloride: an update
J. Occup. Med.
Incidence of cancer among vinyl chloride and polyvinyl chloride workers
Br. J. Ind. Med.
Covalent binding of haloethylenes
Fundamentals of genetic toxicity
Single-strand breaks, chromosome aberrations, sister-chromatid exchanges, and micronuclei in blood lymphocytes of workers exposed to styrene during the production of reinforced plastics
Environ. Mol. Mutagen.
Cited by (22)
Association between methylation of DNA damage response-related genes and DNA damage in hepatocytes of rats following subchronic exposure to vinyl chloride
2019, ChemosphereCitation Excerpt :Chemically induced epigenetic alterations can also serve as biomarkers of carcinogen exposure (Chappell et al., 2016). Occupational VC exposure has been shown to increase the DNA breakage rate of peripheral blood lymphocytes (Du et al., 1995; Awara et al., 1998; Lei et al., 2004). We found that DNA strand breakage in hepatocytes increased with VC dose and exposure time, suggesting that DNA damage in hepatocyte can be a useful marker for VC exposure and DNA damage.
Estimation of benchmark dose for micronucleus occurrence in Chinese vinyl chloride-exposed workers
2013, International Journal of Hygiene and Environmental HealthCitation Excerpt :Another two (p21 and p53) positive worker had an estimated cumulative exposure of 1.07 ppm-years (mg/m3). Du et al. (1995) found that serum levels of gamma-glutamyl transferase (GGT), but not other indicators of liver function, correlated with exposure in a group of 224 VC workers with time-weighted average (TWA) exposure ranging from 0.36 to 74 ppm (0.92–189 mg/m3). Note that our estimated value is an smaller than these value even smaller than 0.56 mg/m3 based on the cancer risk estimated by Li et al. (1998) This difference may imply that genotoxicity is a more sensitive endpoint than the cancers and our estimated TLV-TWA value may serve as a point of departure when additional safety factors are applied to adjust for uncertainties.
DNA repair gene polymorphisms and micronucleus frequencies in Chinese workers exposed to vinyl chloride monomer
2011, International Journal of Hygiene and Environmental HealthCitation Excerpt :VCM is a known animal and human carcinogen capable of damaging DNA and producing many kinds of tumors especially angiosarcoma of the liver (ASL) and hepatocellular cancer (Mundt et al., 2000; Wong et al., 2002). Previous population studies have shown that VCM exposure is associated with increased genotoxicity in humans such as chromosome aberrations, micronuclei (MN) and DNA strand breaks (Fucic et al., 1990, 1996; Du et al., 1995; Zhu et al., 2005). Expression of MN has been reported to be predictive of the development of cancer (Bonassi et al., 2007).
Polymorphisms of DNA repair gene XPD and DNA damage of workers exposed to vinylchloride monomer
2005, International Journal of Hygiene and Environmental HealthDNA single strand breaks in peripheral lymphocytes associated with urinary thiodiglycolic acid levels in polyvinyl chloride workers
2004, Mutation Research - Genetic Toxicology and Environmental Mutagenesis