Adverse effects of butyl benzyl phthalate on the reproductive and hematopoietic systems of male rats
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HEALTH AND SAFETY ISSUES WITH PLASTICIZERS AND PLASTICIZED MATERIALS
2023, Handbook of Plasticizers, Fourth EditionToxicologic pathology of the reproductive system
2022, Reproductive and Developmental ToxicologyInverse association of certain seminal phthalate metabolites with semen quality may be mediated by androgen synthesis: A cross-sectional study from the South China
2021, Environment InternationalCitation Excerpt :Therefore, the health issues caused by PAEs are of great concern. Male reproductive toxicity (e.g., decreased sperm quality, longer anogenital distances, lower fertilizing ability) is one of the most important adverse outcomes induced by phthalate exposure, and it has been demonstrated in several in vitro and in vivo studies (Agarwal et al. 1985; Fredricsson et al. 1993; Ma et al. 2018; Sumner et al. 2019; Wolf et al. 1999). Since the early 21st century, hundreds of studies have tried to understand the relationships between phthalate exposure and adverse semen quality in different populations, but the results are inconsistent (Albert et al. 2018; Bloom et al. 2015; Chen et al. 2017; Duty et al. 2003; Jurewicz et al. 2013; Stroheker et al. 2005; Thurston et al. 2016; Tian et al. 2019a; Wang et al. 2020).
Preconception seminal plasma concentrations of endocrine disrupting chemicals in relation to semen quality parameters among male partners planning for pregnancy
2018, Environmental ResearchCitation Excerpt :Our finding that mBP, metabolite of DBP, was consistently associated with an increase in the percentage of pyriform sperm heads, is supported by toxicological studies highlighting that varying doses of DBP may induce oxidative stress among adult rats (Aly et al., 2016; Zhou et al., 2010). Similarly, animal studies have also demonstrated that BzBP, parent compound of mBzP, administered to adult rats results in reduction of testis, epididymis, prostate and seminal vesicle weights, along with the presence of immature sperm cells (Agarwal et al., 1985), all of which have implications for diminished sperm quality. We found evidence of such a relationship between mBzP and reduced total sperm count when quantified in both urine and seminal plasma.
Growth, blood health, antioxidant status, immune response and resistance to Aeromonas hydrophila of juvenile yellow catfish exposed to di-2-ethylhexyl phthalate (DEHP)
2017, Comparative Biochemistry and Physiology Part - C: Toxicology and PharmacologyCitation Excerpt :An organism is continuously exposed to DEHP through ingestion, inhalation or dermal absorption. In mammals, DEHP exposure typically results in reduction in female fertility (Agarwal et al., 1989), litter size (Tyl et al., 1988), sperm density and motility, and increased reproductive tract malformations (Agarwal et al., 1985). In addition, recent researches had found that DEHP could affect mammal organization development, antioxidant system, endocrine system and immune response (Ghosh et al., 2010; Mathieu-Denoncourt et al., 2015).