Role of chlorophyllin as an in vivo anticlastogen: protection against gamma-radiation and chemical clastogens

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Abstract

Chlorophyllin was evaluated in the mouse bone marrow micronucleus test for its possible protective effects against chromosomal damage induced by gamma-radiation, cyclophosphamide, N-nitroso-N-ethylurea and urethane. Three doses of chlorophyllin (50, 100 and 200 mg/kg, b.w.) were orally administered to mice 2 h before exposure to the clastogens under investigation. The results obtained demonstrated that chlorophyllin can significantly reduce the incidence of micronucleated polychromatic erythrocytes induced by gamma-radiation (1.15 Gy) and all the three chemical clastogens. However with the exception of cyclophosphamide there was no indication of a dose response for the in vivo anticlastogenic effects of chlorophyllin.

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